Swedish CArdioPulmonary bioImage Study 2

NCT06679777 | Recruiting

• 1 other identifier: 2024-01
• Study Type: observational
• Target: 30,154
• Locations: 1 country
• Sites: 6

Brief Summary

In the Swedish CArdioPulmonary bioImage Study (SCAPIS 1), 30,154 randomly selected men and women, aged 50-64 years, were recruited from six areas in Sweden during 2013-2018. The study population was investigated with CCTA, ultrasound carotids, physical examination, questionnaires, accelerometry, ECG, spirometry, and biochemical markers. The aim was to obtain new information relevant to the identification and treatment of individuals with cardiopulmonary and metabolic diseases and to optimize the possibilities for studying disease mechanisms. In SCAPIS-2, half of the individuals (n≈15,000) included in SCAPIS 1, will be re-examined 2024-2025 with the same investigations as during 2013-2018 except for ultrasound of the carotids.

Conditions

Cardiovascular Diseases; Lung Diseases

Outcome Measures

Primary Outcomes (1)

• Cardiovascular death, non-fatal myocardial infarction or stroke.

  Cardiovascular death, non-fatal myocardial infarction or stroke.

  Through study completion, an average of 5 years

Secondary Outcomes (8)

• Cardiovascular death or non-fatal myocardial infarction

  Through study completion, an average of 5 years

• Cardiovascular death

  Through study completion, an average of 5 years

• Myocardial infarction (fatal or non-fatal)

  Through study completion, an average of 5 years

• Stroke (fatal or non-fatal)

  Through study completion, an average of 5 years

• Death (all-cause)

  Through study completion, an average of 5 years

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

In the Swedish CArdioPulmonary bioImage Study (SCAPIS 1), 30,154 randomly selected men and women, aged 50-64 years, were recruited from six areas in Sweden during 2013-2018. The study population was investigated with CCTA, ultrasound carotids, physical examination, questionnaires, accelerometry, ECG, spirometry, and biochemical markers. The aim was to obtain new information relevant to the identification and treatment of individuals with cardiopulmonary and metabolic diseases and to optimize the possibilities for studying disease mechanisms. In SCAPIS-2, half of the individuals (n≈15,000) included in SCAPIS 1, will be re-examined 2024-2025 with the same investigations as during 2013-2018 except for ultrasound of the carotids.

You may qualify if:

• \- Participated in SCAPIS 1.

You may not qualify if:

• Individuals who have withdrawn their informed consent during or after SCAPIS 1.

Sponsors & Collaborators

• Karolinska Institutet: lead
• Lund University: collaborator
• Uppsala University: collaborator
• Umeå University: collaborator
• Linkoeping University: collaborator
• Göteborg University: collaborator

Study Sites (6)

Gothenburg University

Gothenburg, Sweden

RECRUITING

Linköping University

Linköping, Sweden

RECRUITING

Lund University

Lund, Sweden

RECRUITING

Karolinska Institutet

Stockholm, Sweden

RECRUITING

Umeå Universitet

Umeå, Sweden

RECRUITING

Uppsala University

Uppsala, Sweden

RECRUITING

Related Publications (1)

• Bergstrom G, Berglund G, Blomberg A, Brandberg J, Engstrom G, Engvall J, Eriksson M, de Faire U, Flinck A, Hansson MG, Hedblad B, Hjelmgren O, Janson C, Jernberg T, Johnsson A, Johansson L, Lind L, Lofdahl CG, Melander O, Ostgren CJ, Persson A, Persson M, Sandstrom A, Schmidt C, Soderberg S, Sundstrom J, Toren K, Waldenstrom A, Wedel H, Vikgren J, Fagerberg B, Rosengren A. The Swedish CArdioPulmonary BioImage Study: objectives and design. J Intern Med. 2015 Dec;278(6):645-59. doi: 10.1111/joim.12384. Epub 2015 Jun 19.

  PMID: 26096600 BACKGROUND

Related Links

• website

Biospecimen

Retention: SAMPLES WITHOUT DNA

Plasma, serum, urine

MeSH Terms

Conditions

Cardiovascular Diseases; Lung Diseases

Condition Hierarchy (Ancestors)

Respiratory Tract Diseases

Study Officials

• Carl Johan Östgren, PhD

  Linkoeping University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Tomas Jernberg, PhD

CONTACT

+46-70-1671474; tomas.jernberg@ki.se

Vibeke Sparring, PhD

CONTACT

+46-70-854 44 89; vibeke.sparring@hjart-lungfonden.se

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: November 4, 2024
• First Posted: November 7, 2024
• Study Start: January 15, 2024
• Primary Completion: December 31, 2025
• Study Completion (Estimated): December 31, 2030
• Last Updated: November 7, 2024

Record last verified: 2024-11

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, ICF
• Time Frame: After study completion
• Access Criteria: Approval from the Swedish Ethical Review Authority and authority responsible for personal data

Locations

SE (6)