GlyCoBrain Observational Study

NCT06679088 | Enrolling By Invitation

• 1 other identifier: BU 1807/8-1
• Study Type: observational
• Target: 350
• Locations: 1 country
• Sites: 1

Brief Summary

Breakfasts with a high glycaemic index (GI) resulting in sharp rises in blood glucose may adversely affect memory and attention, particularly in the late postprandial phase (i.e., 120-180 minutes after breakfast). Young adults may be particularly responsive to these adverse effects on cognition since they are prone to experience circadian misalignment because their midpoint of sleep (i.e., chronotype) is biologically most delayed in young adulthood. Our recent research suggests that persons with a later chronotype exhibit no diurnal difference in response to a high GI meal consumed in the morning and evening, suggesting that consumption of an early breakfast "against the inner clock" may be adverse for their glycaemic response and that consumption of an early breakfast may present a burden for those with a later chronotype. Indeed, persons with later chronotypes commonly tend to exhibit less favourable eating pattern. Hence, consuming an early breakfast, e.g. in preparation for an exam, may be more problematic for persons with later chronotypes and it may be more likely that these persons choose less favorable foods for breakfast. Thus, it remains to be clarified whether persons with a later chronotype:

1. 1.usually consume breakfasts with a higher dietary GI than those with an earlier chronotype. Addressing this hypothesis needs to consider both the first and second breakfast (i.e., all meals until noon), since breakfast skipping may be common particularly among persons with a later chronotype
2. 2.are more prone to consume foods from higher GI sources in preparation for an exam in the morning than those with an earlier chronotype.
3. 3.consume breakfasts of a higher energy density and a lower micronutrient adequacy than persons with an earlier chronotype.

Conditions

Healthy; Adult

Keywords

Chronotype; Breakfast; Glyceamic Index; MCTQ; Academic performance; Dietary patterns; Student nutrition; Nutrient composition

Outcome Measures

Primary Outcomes (2)

• Breakfast quality, dietary GI and nutrient composition

  2 times Computer-assisted 24-hour recall of consumed foods and beverages in the past 24 h

  At inclusion into the study and after 6 days

• Breakfast food choice in preparation of an exam

  Questionnaire inquiring selected food items, beverages and meal replacements

  Assessed once at the beginning of the study

Study Arms (1)

students of Paderborn University

18 years to 25 years (adult)

Eligibility Criteria

• Age: 18 Years - 25 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Students at Paderborn University (see inclusion criteria)

You may qualify if:

• Students at Paderborn University aged between 18 and 25 years
• Proficient in the German language because all questionnaires are in German.

You may not qualify if:

• Students studying nutritional science and home economics
• acute or permanent use of sleep-promoting medications (including herbal preparation):
• chemical medications: melatonin, diphenhydramine, doxylamine
• herbal preparations: hops, St. John's wort, lemon balm, lavender, passionflower, Baldurat, Neurexan, cannabinoids
• Use of psychotropic medications (antidepressants, tranquilizer, antipsychotics)
• Use of methylphenidate (e.g. Ritalin, Medikinet, Concerta)
• Use of cannabinoids by prescription
• Continuous administration of antihistamines when discontinuation is not feasible during the intervention
• Use of herbal preparations affecting memory and concentration (e.g. gingko, ginseng, ashwagandha)
• Use of other medications (e.g. insulin, metformin, SGLT2 inhibitors, steroids, ACE inhibitors)
• Selected chronic diseases (depression and other mental disorders such as anxiety disorder, ADHD, diabetes mellitus (all types), prediabetes, blood clotting disorders (e.g., thrombocytopenia, hemophilia), eating disorders (e.g., anorexia, binge eating, bulimia)
• Addiction disorders (e.g., alcohol, drug, or medication dependency)
• Chronic inflammatory bowel diseases
• infectious diseases (HIV, hepatitis)
• Pregnant and breastfeeding individuals

Sponsors & Collaborators

• Paderborn University: lead

Study Sites (1)

Paderborn University

Paderborn, North-Rhine-Westfalia, 33098, Germany

Location

Related Publications (11)

• Koch SAJ, Conrad J, Cade JE, Weinhold L, Alexy U, Nothlings U. Validation of the web-based self-administered 24-h dietary recall myfood24-Germany: comparison with a weighed dietary record and biomarkers. Eur J Nutr. 2021 Oct;60(7):4069-4082. doi: 10.1007/s00394-021-02547-7. Epub 2021 May 11.

  PMID: 33974128 BACKGROUND

• Koch SAJ, Conrad J, Hierath L, Hancock N, Beer S, Cade JE, Nothlings U. Adaptation and Evaluation of Myfood24-Germany: A Web-Based Self-Administered 24-h Dietary Recall for the German Adult Population. Nutrients. 2020 Jan 6;12(1):160. doi: 10.3390/nu12010160.

  PMID: 31935885 BACKGROUND

• Nowack K, Van Der Meer E. The synchrony effect revisited: chronotype, time of day and cognitive performance in a semantic analogy task. Chronobiol Int. 2018 Nov;35(12):1647-1662. doi: 10.1080/07420528.2018.1500477. Epub 2018 Aug 7.

  PMID: 30085831 BACKGROUND

• Xiao Q, Garaulet M, Scheer FAJL. Meal timing and obesity: interactions with macronutrient intake and chronotype. Int J Obes (Lond). 2019 Sep;43(9):1701-1711. doi: 10.1038/s41366-018-0284-x. Epub 2019 Jan 31.

  PMID: 30705391 BACKGROUND

• Pengpid S, Peltzer K. Skipping Breakfast and Its Association with Health Risk Behaviour and Mental Health Among University Students in 28 Countries. Diabetes Metab Syndr Obes. 2020 Aug 18;13:2889-2897. doi: 10.2147/DMSO.S241670. eCollection 2020.

  PMID: 32884315 BACKGROUND

• Ballon A, Neuenschwander M, Schlesinger S. Breakfast Skipping Is Associated with Increased Risk of Type 2 Diabetes among Adults: A Systematic Review and Meta-Analysis of Prospective Cohort Studies. J Nutr. 2019 Jan 1;149(1):106-113. doi: 10.1093/jn/nxy194.

  PMID: 30418612 BACKGROUND

• Ma X, Chen Q, Pu Y, Guo M, Jiang Z, Huang W, Long Y, Xu Y. Skipping breakfast is associated with overweight and obesity: A systematic review and meta-analysis. Obes Res Clin Pract. 2020 Jan-Feb;14(1):1-8. doi: 10.1016/j.orcp.2019.12.002. Epub 2020 Jan 7.

  PMID: 31918985 BACKGROUND

• Gibney MJ, Barr SI, Bellisle F, Drewnowski A, Fagt S, Livingstone B, Masset G, Varela Moreiras G, Moreno LA, Smith J, Vieux F, Thielecke F, Hopkins S. Breakfast in Human Nutrition: The International Breakfast Research Initiative. Nutrients. 2018 May 1;10(5):559. doi: 10.3390/nu10050559.

  PMID: 29723985 BACKGROUND

• Kanerva N, Kronholm E, Partonen T, Ovaskainen ML, Kaartinen NE, Konttinen H, Broms U, Mannisto S. Tendency toward eveningness is associated with unhealthy dietary habits. Chronobiol Int. 2012 Aug;29(7):920-7. doi: 10.3109/07420528.2012.699128.

  PMID: 22823875 BACKGROUND

• Mazri FH, Manaf ZA, Shahar S, Mat Ludin AF. The Association between Chronotype and Dietary Pattern among Adults: A Scoping Review. Int J Environ Res Public Health. 2019 Dec 20;17(1):68. doi: 10.3390/ijerph17010068.

  PMID: 31861810 BACKGROUND

• Stutz B, Krueger B, Goletzke J, Jankovic N, Alexy U, Herder C, Dierkes J, Berg-Beckhoff G, Jakobsmeyer R, Reinsberger C, Buyken AE. Glycemic response to meals with a high glycemic index differs between morning and evening: a randomized cross-over controlled trial among students with early or late chronotype. Eur J Nutr. 2024 Aug;63(5):1593-1604. doi: 10.1007/s00394-024-03372-4. Epub 2024 Apr 12.

  PMID: 38605233 BACKGROUND

Related Links

• The main aspects of the observational study are described on the website. Information is provided on the aim of the study, eligibility criteria and information on the subsequent intervention study with the data to be collected.

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof. Dr. Anette Buyken, Head of the research group "Public Health Nutrition"

Study Record Dates

• First Submitted: November 5, 2024
• First Posted: November 7, 2024
• Study Start: October 1, 2024
• Primary Completion: February 28, 2025
• Study Completion (Estimated): February 28, 2027
• Last Updated: April 3, 2025

Record last verified: 2024-11

Data Sharing

• IPD Sharing: Will not share

Locations

DE (1)