Alteration of Sweet Taste Perception After Reduction of Sweet Food and Beverage Consumption.

NCT06678386 | Enrolling By Invitation

• 1 other identifier: 233/2567 (IRB1)
• Study Type: interventional
• Target: 58
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to determine whether reducing sugar intake by 50% for 12 weeks can change sweet taste perception in healthy adults and its consequences. The main questions it aims to answer are:

• Does sweet intensity change after reducing daily sugar intake by 50% for 12 weeks?
• How does sweet intensity change after completing dietary modification for 8 weeks?
• Does individual daily sugar intake change after completing dietary modification for 8 weeks? Researchers will compare reducing daily sugar intake by 50% for 12 weeks to an unmodified diet to see if sugar reduction can change sweet intensity. Participants will:
• Reduce daily sugar intake by 50% or maintain an unmodified diet for 12 weeks.
• Visit the clinic three times for anthropometric measurements, sweet perception tests, and to complete questionnaires.
• Keep a diet record for a total of 15 days during the research period.

Conditions

Health-Related Behavior

Keywords

sweet taste perception; sugar reduction; dietary behavior; dietary modification; sweet intensity

Outcome Measures

Primary Outcomes (1)

• Sweet intensity change from baseline after 12 weeks of the intervention.

  Percentage of participants whose sweet intensity has increased after reducing daily sugar intake by 50% for 12 weeks, compared to those with an unmodified diet.

  16 weeks from baseline (12 weeks after the start of the intervention)

Secondary Outcomes (2)

• Sweet intensity change from baseline after completing the intervention for 8 weeks.

  24 weeks from baseline

• Changes in sugar consumption behavior from baseline

  24 weeks from baseline

Study Arms (2)

50% sugar reduction

EXPERIMENTAL

Participants were advised by a dietitian to reduce their daily caloric intake from sugars by 50% for 12 weeks.

Behavioral: 50% sugar reduction

unmodified diet

NO INTERVENTION

Participants maintained an unmodified diet.

Interventions

50% sugar reduction BEHAVIORAL

Participants were advised by a dietitian to reduce their daily caloric intake from sugars by 50% for 12 weeks.

50% sugar reduction

Eligibility Criteria

• Age: 18 Years - 59 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• People with a fasting blood sugar level below 126 mg/dL or an HbA1C below 6.5% in the past 6 months, who are not currently being treated for diabetes.
• People who score 10 or more points on the sweet food consumption behavior questionnaire.
• People who are able to communicate in the Thai language.
• People who are able to chat and use video calls via the Line application.
• People who agree to modify their diet and beverages according to the recommendations of a dietitian.
• People who agree to undergo sweet taste testing, complete a food record, and fill out a questionnaire.

You may not qualify if:

• People with uncontrolled chronic conditions who have had changes in their treatment within the past 3 months.
• People with a history of severe illness in the past 6 months.
• People who regularly use medication, excluding contraceptives and vitamins.
• Pregnant women.
• People who have experienced a weight change of at least 10% over the past 3 months.

Sponsors & Collaborators

• Mahidol University: lead

Study Sites (1)

Faculty of Medicine Siriraj Hospital, Mahidol University

Bangkoknoi, Bangkok, 10700, Thailand

Location

MeSH Terms

Conditions

Health Behavior

Condition Hierarchy (Ancestors)

Behavior

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 6, 2024
• First Posted: November 7, 2024
• Study Start: October 1, 2024
• Primary Completion: March 31, 2025
• Study Completion: July 31, 2025
• Last Updated: November 7, 2024

Record last verified: 2024-11

Locations

TH (1)