The Role of Olive Oil in the Treatment of Covid-19 Pneumonia

NCT06677658 | Completed

• 1 other identifier: 22.05.2024-03
• Study Type: observational
• Target: 130
• Locations: 1 country
• Sites: 1

Brief Summary

Objective: Consuming natural olive oil in patients diagnosed with COVID-19 Pneumonia may strengthen immunity, slow down disease progression, and lower mortality. Within the scope of this research, the investigators aimed to elucidate the effect of using natural olive oil on clinical, laboratory, and radiological findings and survival in patients diagnosed with COVID-19 pneumonia and given pulse steroid treatment. Method: This retrospective observational research enrolled 130 patients diagnosed with COVID-19 pneumonia. Participants were examined in two groups according to their olive oil consumption status. Patients diagnosed with COVID-19 pneumonia treated with pulse steroids for three days who routinely consumed oral olive oil in their daily diets were defined as Group 1, and those who did not consume olive oil were defined as Group 2.

Conditions

COVID-19 Pneumonia; Nutrition, Healthy

Keywords

COVID-19; Pneumonia; Olive Oil; Steroid; Immune system

Outcome Measures

Primary Outcomes (1)

• Positive effect of olive oil on clinical and laboratory parameters in patients given pulse steroid therapy due to Covid 19 pneumonia.

  The benefits of olive oil consumption can be increased through physical activity, especially strength and resistance exercise. Such an approach is likely to prevent viral infections effectively. In terms of the recommended dose of olive oil, a moderate dose of 20-30 grams/day (especially extra virgin olive oil rich in polyphenols) can be recommended in combination with other dietary functional foods to strengthen the immune system, which is in line with the latest non-communicable disease prevention recommendations. Positive effects of regular daily olive oil use on clinical and laboratory parameters were observed in patients receiving pulse steroid treatment due to Covid-19 pneumonia.

  After 3 days of 250 mg/day pulse steroid ( methylprednisolone ) treatment and during hospital stay.

Secondary Outcomes (1)

• Intensive care requirement and mortality in patients diagnosed with covid-19 pneumonia taking olive oil.

  After 3 days of 250 mg/day pulse steroid treatment and during hospital stay

Study Arms (2)

Group 1

Patients diagnosed with COVID-19 pneumonia treated with pulse steroids (250 mg/day) for three days and routinely consumed at least 20 ml/day olive oil in their diets were defined as Group 1.

Dietary Supplement: Olive Oil; Drug: Methylprednisolone

Group 2

Patients of similar age and gender with COVID-19 pneumonia who received the same treatment but did not consume olive oil were defined as Group 2.

Drug: Methylprednisolone

Interventions

Olive Oil DIETARY_SUPPLEMENT

Group 1 included patients who consumed at least 20 ml of oral olive oil daily. Group 2 included patients who did not consume olive oil.

Group 1

Methylprednisolone DRUG

Both groups were diagnosed with Covid-19 pneumonia and were given pulse steroid ( methylprednisolone ) treatment at 250 mg/day for 3 days.

Also known as: Pulse steroid

Group 1; Group 2

Eligibility Criteria

• Age: 27 Years - 95 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

This research enrolled 130 patients diagnosed with COVID-19 pneumonia, confirmed with real-time polymerase chain reaction (RT-PCR). The patients were segmented into two groups (n=65 in each) according to their olive oil consumption. However, all of the patients included in the study were patients diagnosed with covid-19 pneumonia and given pulse steroid treatment.

You may qualify if:

• The study included patients aged ≥18 who were diagnosed with COVID-19 and had lung involvement (COVID-19 pneumonia).

You may not qualify if:

• Patients under the age of 18, pregnant women, individuals intubated due to severe respiratory failure in COVID-19 pneumonia, and those who received alternative treatments other than pulse steroid treatment (Immunoplasma, Tocilizumab, Anakinra, Plasmapheresis, Stem Cell Therapy, etc.) were excluded

Sponsors & Collaborators

• Giresun University: lead

Study Sites (1)

Giresun Training and Research Hospital

Giresun, Giresun, 28100, Turkey (Türkiye)

Location

Related Publications (3)

• Soo CI, Poon KV, Ayub A, You HW, Tan CX, Loh KJJ, Eng CCH, Sia LC, Wong CK. High-dose pulse methylprednisolone vs. dexamethasone standard therapy for severe and critical COVID-19 pneumonia: Efficacy assessment in a retrospective single-centre experience from Malaysia. Med J Malaysia. 2024 Jan;79(1):15-20.

  PMID: 38287752 BACKGROUND

• Alkhatib A. Antiviral Functional Foods and Exercise Lifestyle Prevention of Coronavirus. Nutrients. 2020 Aug 28;12(9):2633. doi: 10.3390/nu12092633.

  PMID: 32872374 BACKGROUND

• Hendi AA, Virk P, Awad MA, Elobeid M, Ortashi KMO, Alanazi MM, Alkallas FH, Almoneef MM, Abdou MA. In Silico Studies on Zinc Oxide Based Nanostructured Oil Carriers with Seed Extracts of Nigella sativa and Pimpinella anisum as Potential Inhibitors of 3CL Protease of SARS-CoV-2. Molecules. 2022 Jul 4;27(13):4301. doi: 10.3390/molecules27134301.

  PMID: 35807545 BACKGROUND

MeSH Terms

Conditions

COVID-19; Pneumonia

Interventions

Olive Oil; Methylprednisolone

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Dietary Fats, Unsaturated; Dietary Fats; Fats; Lipids; Fats, Unsaturated; Plant Oils; Oils; Food; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages; Prednisolone; Pregnadienetriols; Pregnadienes; Pregnanes; Steroids; Fused-Ring Compounds; Polycyclic Compounds

Study Officials

• Selda Günaydın, MD

  Assistant researcher

  STUDY CHAIR

• Ersin Kuloğlu, MD

  Assistant researcher

  STUDY CHAIR

• Gökhan Aydın, MD

  Assistant researcher

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 2, 2024
• First Posted: November 7, 2024
• Study Start: January 1, 2022
• Primary Completion: June 1, 2022
• Study Completion: September 7, 2022
• Last Updated: November 7, 2024

Record last verified: 2024-11

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)