NCT06676046|Recruiting
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Sponsor study identifier
Secondary identifiers
observational
1,500
1 country
1
Study Start
January 15, 2025
Actual (reported)Primary Completion
November 24, 2044
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
November 24, 2044
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Background: The right amount of fats in the blood (cholesterol and triglycerides) are a key part of a healthy organism. Too much or too little of these fats may manifest as diseases (dyslipidemia). There are many causes for these abnormalities, but some are genetically determined and we would like to better understand the progression of these conditions over time. Objective: This natural history study aims to learn more about dyslipidemias; how they change over time; and how they respond to therapy. We also want to develop new diagnosis methods for these conditions. With the knowledge we will acquire we hope to provide new insights, new approaches and improve the overall health of these patients. Eligibility: Individuals aged 10 years and older, residing both within and outside the United States, who have or are suspected of having a disorder that causes changes in the levels of fats in their blood (genetic dyslipidemias). Design: Participants residing within and outside the United States will be screened. Their medical records may be reviewed. They may talk to researchers about their medical history by phone, telehealth, or in person. All study visits are optional. Participants may visit the NIH up to 15 times per year, if needed. Each visit may include a physical exam and blood tests. Participants may also have an electrocardiogram (EKG). The EKG measures the electrical activity when the heart beats. In some cases, participants may remain in the study for up to 20 years.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
November 24, 2044
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
November 5, 2024
Actual (reported)November 6, 2024
Actual (reported)January 15, 2025
Actual (reported)November 24, 2044
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
November 24, 2044
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Change overtime in low-density lipoprotein cholesterol (LDL-C).
To observe change overtime in low-density lipoprotein cholesterol (LDL-C).
up to 20 years
Change overtime in high-density lipoprotein cholesterol (HDL-C)
up to 20 years
Change overtime in triglycerides
up to 20 years
Change overtime in lipid markers of dyslipidemia and cardiovascular risk.
up to 20 years
Male and female participants with rare primary lipid disorders ages 10 and older.
Individuals with rare and/or unusual lipid disorders residing both within and outside the United States
National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States
Marcelo J Amar, M.D.
National Heart, Lung, and Blood Institute (NHLBI)
First Submitted
November 5, 2024
First Posted
November 6, 2024
Study Start
January 15, 2025
Actual (reported)Primary Completion
November 24, 2044
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Ultrasound and Other Images of Artery Blockages
Contact the study team to confirm eligibility.
Study Completion
November 24, 2044
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
March 23, 2026
Record last verified: 2026-03-13
All individual participant data (IPD) that underpin the results presented in a publication will be made available.
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Source: ClinicalTrials.gov.
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