Systemic Inflammation Response Index and C-Reactive Protein to Albumin Ratio in Acute Lymphoblastic Leukemia

NCT06674850 | Not Yet Recruiting

• 1 other identifier: inflammation in leukemia
• Study Type: observational
• Target: 36
• Locations: 0 countries
• Sites: N/A

Brief Summary

the goal of this observational study is Assesment of systemic inflammatory index (SII) , system inflammation response index (SIRI) and CRP Albumin ratio(CAR) as biomarkers for ALL prognosis.

Conditions

Acute Lymphoblastic Leukemia

Outcome Measures

Primary Outcomes (1)

• Assessment of C-reactive protein to Albumin ratio(CAR) as a biomarker for acute lymphoblastic leukemia prognosis

  Assessment of C-reactive protein to Albumin ratio(CAR) as a biomarker for acute lymphoblastic leukemia prognosis

  one year

Secondary Outcomes (1)

• Assessment of systemic inflammatory index (SII) as a biomarker for acute lymphoblastic leukemia prognosis

  one year

Study Arms (2)

Diseased group

36 patients with acute lymphoblastic leukemia will be included

Control group

36 healthy people will be included

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Newly diagnosed ALL patients that admitted to the South Egypt Cancer Institute and not received any treatment.

You may qualify if:

• Newly diagnosed ALL patients that admitted to the South Egypt Cancer Institute and not received any treatment.

You may not qualify if:

• Presence of other hematological disorders( other than ALL)
• History of other malignancies, or relapsed ALL.
• Patients under chemotherapy or radiotherapy. 3- Signs of inflammation 5- Evidence of autoimmune disease.

Sponsors & Collaborators

• Assiut University: lead

Related Publications (3)

• di Masi A. Human Serum Albumin: From Molecular Aspects to Biotechnological Applications. Int J Mol Sci. 2023 Feb 17;24(4):4081. doi: 10.3390/ijms24044081.

  PMID: 36835490 RESULT

• Tang HN, Pan BH, Wang L, Zhu HY, Fan L, Xu W, Li JY. C-reactive protein-to-albumin ratio is an independent poor prognostic factor in newly diagnosed chronic lymphocytic leukaemia: A clinical analysis of 322 cases. Transl Oncol. 2021 Apr;14(4):101035. doi: 10.1016/j.tranon.2021.101035. Epub 2021 Feb 11.

  PMID: 33582571 RESULT

• Roberts KG, Mullighan CG. The Biology of B-Progenitor Acute Lymphoblastic Leukemia. Cold Spring Harb Perspect Med. 2020 Jul 1;10(7):a034835. doi: 10.1101/cshperspect.a034835.

  PMID: 31653664 RESULT

MeSH Terms

Conditions

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Condition Hierarchy (Ancestors)

Leukemia, Lymphoid; Leukemia; Neoplasms by Histologic Type; Neoplasms; Hematologic Diseases; Hemic and Lymphatic Diseases; Lymphoproliferative Disorders; Lymphatic Diseases; Immunoproliferative Disorders; Immune System Diseases

Study Officials

• Asmaa zhran

  Assiut University

  STUDY CHAIR

• Doaa Temeric

  Assiut University

  STUDY DIRECTOR

Central Study Contacts

Esraa Hamoda

CONTACT

+2001066177369; esraahamoda73@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: October 27, 2024
• First Posted: November 5, 2024
• Study Start: November 1, 2024
• Primary Completion: November 1, 2025
• Study Completion: November 1, 2025
• Last Updated: November 5, 2024

Record last verified: 2024-11