NCT06670183|Active Not Recruiting
Dietary Factors and Rheumatoid Arthritis Risk in the UK Biobank
The Associations Between Diet and Rheumatoid Arthritis Risk in the UK Biobank
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The Associations Between Diet and Rheumatoid Arthritis Risk in the UK Biobank
Sponsor study identifier
observational
500,000
0 countries
N/A
Study Start
January 1, 2006
Actual (reported)Primary Completion
December 31, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
December 31, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Rheumatoid arthritis (RA) is the most common inflammatory arthritis, affecting around 1% of the UK population. It affects around 400,000 adults and is characterised by synovial inflammation, cartilage and bone damage that requires lifelong treatment and represents a significant burden for both the individual and society. Diet can affect inflammatory status and RA risk, with varying risks for men and women on specific diets. People with low to moderate consumption of alcohol may be at a lower risk of RA. Those who consume lower intakes of fruit and vegetables could be at a greater risk than those with adequate intakes. This research aims to better understand the role of diet in reducing RA risk in men and women in the United Kingdom. The research will use existing dietary and lifestyle data from the United Kingdom Biobank Study and hospital records of RA incidence.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 31, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 1, 2006
Actual (reported)October 31, 2024
Actual (reported)November 1, 2024
Actual (reported)December 31, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
December 31, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Rheumatoid Arthritis incidence (first)
First RA incidence, identified from all relevant ICD diagnosis codes and treatment codes identified through linked HES data.
Time Frame: Age when the completed questionnaire was returned (2006-2010) until age at event, death, or end of study period (2024).
UK Biobank. There are no interventions in this observational cohort study.
Dietary patterns such as regular meat-eater, occasional meat-eater, pescatarian, and vegetarian; Mediterranean diet.
Dietary components, such as oily fish, dairy product, supplements, fibre, vitamin D supplements.
General population. Information on the UK Biobank cohort profile is available here: https://www.ukbiobank.ac.uk/
Sudlow C, Gallacher J, Allen N, Beral V, Burton P, Danesh J, Downey P, Elliott P, Green J, Landray M, Liu B, Matthews P, Ong G, Pell J, Silman A, Young A, Sprosen T, Peakman T, Collins R. UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med. 2015 Mar 31;12(3):e1001779. doi: 10.1371/journal.pmed.1001779. eCollection 2015 Mar.
UK Biobank collected biomarker samples with DNA. This project makes use of data from the biomarker samples, but no additional samples will be taken and no additional samples will taken for this research. No samples will be processed, stored or retained by us. For the previously published details of UK Biobank, with anonymised data made available for researchers, please see: https://www.ukbiobank.ac.uk/enable-your-research/about-our-data/biomarker data.
Darren C Greenwood, PhD
University of Leeds
500,000 participants (actual enrollment reported by the registry).
First Submitted
October 31, 2024
First Posted
November 1, 2024
Study Start
January 1, 2006
Actual (reported)Efficacy of Structured Progressive Training Exercise on Muscle Strength of Patients With Rheumatoid Arthritis
Frequency and intake of alcoholic beverages was measured by self-reporting the weekly frequency of different types of alcoholic beverages, e.g., the number of pints of beer/cider consumed per week and measures of spirits or liquors consumed per week were collected to assess consumption of beer/cider and spirits.
Serum 25(OH)D was measured once at baseline through a non-fasted blood draw during any season of the year.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
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Primary Completion
December 31, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
December 31, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
May 1, 2026
Record last verified: 2026-04
IPD from UK Biobank is available to genuine researchers on application (https://www.ukbiobank.ac.uk/enable-your-research/apply-for-access).
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Source: ClinicalTrials.gov.
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