Dietary Factors and Rheumatoid Arthritis Risk in the UK Biobank

NCT06670183 | Active Not Recruiting

• 1 other identifier: fsydo_UKBB
• Study Type: observational
• Target: 500,000
• Locations: 0 countries
• Sites: N/A

Brief Summary

Rheumatoid arthritis (RA) is the most common inflammatory arthritis, affecting around 1% of the UK population. It affects around 400,000 adults and is characterised by synovial inflammation, cartilage and bone damage that requires lifelong treatment and represents a significant burden for both the individual and society. Diet can affect inflammatory status and RA risk, with varying risks for men and women on specific diets. People with low to moderate consumption of alcohol may be at a lower risk of RA. Those who consume lower intakes of fruit and vegetables could be at a greater risk than those with adequate intakes. This research aims to better understand the role of diet in reducing RA risk in men and women in the United Kingdom. The research will use existing dietary and lifestyle data from the United Kingdom Biobank Study and hospital records of RA incidence.

Conditions

Rheumatoid Arthritis (RA)

Keywords

Nutrition; Rheumatoid Arthritis; Body Mass Index; Alcohol consumption; Cohort study; Epidemiology; Arthritis, Rheumatoid, Seropostive

Outcome Measures

Primary Outcomes (1)

• Rheumatoid Arthritis incidence (first)

  First RA incidence, identified from all relevant ICD diagnosis codes and treatment codes identified through linked HES data.

  Time Frame: Age when the completed questionnaire was returned (2006-2010) until age at event, death, or end of study period (2024).

Study Arms (1)

UK Biobank

UK Biobank. There are no interventions in this observational cohort study.

Other: Dietary patterns; Other: Food groups and Nutrients; Other: Alcohol intake; Other: Vitamin D status

Interventions

Dietary patterns OTHER

Dietary patterns such as regular meat-eater, occasional meat-eater, pescatarian, and vegetarian; Mediterranean diet.

UK Biobank

Food groups and Nutrients OTHER

Dietary components, such as oily fish, dairy product, supplements, fibre, vitamin D supplements.

UK Biobank

Alcohol intake OTHER

Frequency and intake of alcoholic beverages was measured by self-reporting the weekly frequency of different types of alcoholic beverages, e.g., the number of pints of beer/cider consumed per week and measures of spirits or liquors consumed per week were collected to assess consumption of beer/cider and spirits.

UK Biobank

Vitamin D status OTHER

Serum 25(OH)D was measured once at baseline through a non-fasted blood draw during any season of the year.

UK Biobank

Eligibility Criteria

• Age: 40 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

General population. Information on the UK Biobank cohort profile is available here: https://www.ukbiobank.ac.uk/

You may qualify if:

• Male or female
• Ages 40 to 70 years at time of recruitment
• Able to provide informed consent

You may not qualify if:

• Unable to link dietary and lifestyle data with hospital episode statistics
• Had a rheumatoid arthritis before or no the date of recruitment
• Withdrew consent during the study period
• Genetic sex differs to reported sex
• Outlier diet or anthropometric data (energy intake \<500 or \>5000 kcal/day or body mass index \<10 or \>60 kg/m2)

Sponsors & Collaborators

• University of Leeds: lead

Related Publications (1)

• Sudlow C, Gallacher J, Allen N, Beral V, Burton P, Danesh J, Downey P, Elliott P, Green J, Landray M, Liu B, Matthews P, Ong G, Pell J, Silman A, Young A, Sprosen T, Peakman T, Collins R. UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med. 2015 Mar 31;12(3):e1001779. doi: 10.1371/journal.pmed.1001779. eCollection 2015 Mar.

  PMID: 25826379 BACKGROUND

Related Links

• Study website

Biospecimen

Retention: SAMPLES WITH DNA

UK Biobank collected biomarker samples with DNA. This project makes use of data from the biomarker samples, but no additional samples will be taken and no additional samples will taken for this research. No samples will be processed, stored or retained by us. For the previously published details of UK Biobank, with anonymised data made available for researchers, please see: https://www.ukbiobank.ac.uk/enable-your-research/about-our-data/biomarker data.

MeSH Terms

Conditions

Arthritis, Rheumatoid; Alcohol Drinking; Arthritis

Interventions

Dietary Patterns; Nutrients; Ethanol

Condition Hierarchy (Ancestors)

Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Autoimmune Diseases; Immune System Diseases; Drinking Behavior; Behavior

Intervention Hierarchy (Ancestors)

Diet; Nutritional Physiological Phenomena; Diet, Food, and Nutrition; Physiological Phenomena; Feeding Behavior; Food; Food and Beverages; Alcohols; Organic Chemicals

Study Officials

• Darren C Greenwood, PhD

  University of Leeds

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Senior Lecturer in Biostatistics

Study Record Dates

• First Submitted: October 31, 2024
• First Posted: November 1, 2024
• Study Start: January 1, 2006
• Primary Completion (Estimated): December 31, 2029
• Study Completion (Estimated): December 31, 2029
• Last Updated: May 1, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, ICF
• Time Frame: IPD from UK Biobank is available to genuine researchers on application (https://www.ukbiobank.ac.uk/enable-your-research/apply-for-access).
• Access Criteria: IPD from UK Biobank is available to genuine researchers on application (https://www.ukbiobank.ac.uk/enable-your-research/apply-for-access).