Diet and Rheumatoid Arthritis Risk in the United Kingdom Women's Cohort

NCT06670144 | Completed

• 1 other identifier: fsydo_UKWCS
• Study Type: observational
• Target: 35,372
• Locations: 1 country
• Sites: 1

Brief Summary

Rheumatoid arthritis (RA) is the most common inflammatory arthritis, affecting around 1% of the UK population. It affects around 400,000 adults and is characterised by synovial inflammation, cartilage and bone damage that requires lifelong treatment and represents a significant burden for both the individual and society. Diet can affect inflammatory status and RA risk, with varying risks for women on specific diets. Low to moderate levels of alcohol consumption may be associated with lower risk of RA, and those who do not consume enough fruit and vegetables could be at a greater risk than those with adequate intakes. Our research aim is to better understand the role of diet in reducing RA risk in United Kingdom women. The research will use existing dietary and lifestyle data from the United Kingdom Women's Cohort Study and hospital records of RA incidence.

Conditions

Rheumatoid Arthritis (RA)

Keywords

Nutrition; Rheumatoid Arthritis; Alcohol consumption; Body Mass Index; Cohort study; Epidemiology; Arthritis, Rheumatoid, Seropositive

Outcome Measures

Primary Outcomes (1)

• Rheumatoid Arthritis incidence (first)

  Incidence of first rheumatoid arthritis ascertained from linkage to Hospital Episode Statistics (HES) data.

  Time Frame: age when the completed questionnaire was returned (1995-1998) until age at event, death, or end of study period (19 Mar 2019).

Study Arms (1)

United Kingdom Women's Cohort

United Kingdom Women's Cohort Study. No interventions are to be administered in this observational prospective cohort study.

Other: Dietary pattern; Other: Alcohol intake; Other: Fruit and vegetables intake; Other: Tea consumption; Other: Coffee consumption; Other: Fish intake; Other: Meat intake; Other: Vitamin D intake

Interventions

Dietary pattern OTHER

(regular meat-eater, occasional meat-eater, fish-eater, vegetarian, and vegan; Mediterranean diet)

United Kingdom Women's Cohort

Alcohol intake OTHER

(Frequency and intake of beer, wine, sherry, and spirits were collected by asking the number of specified units (pints, glasses or measures) of each type of alcoholic beverage (beer or cider, wine, sherry or fortified wines, and spirits) per week.)

United Kingdom Women's Cohort

Fruit and vegetables intake OTHER

(Intake of fruits, vegetables, fruits and vegetables combined from food frequency questionnaire)

United Kingdom Women's Cohort

Tea consumption OTHER

(Intake of tea from food frequency questionnaire)

United Kingdom Women's Cohort

Coffee consumption OTHER

(Intake of caffeinated coffee and decaffeinated coffee from food frequency questionnaire)

United Kingdom Women's Cohort

Fish intake OTHER

(Intake of fish from food frequency questionnaire)

United Kingdom Women's Cohort

Meat intake OTHER

(Intake of red meat, processed meat, and poultry from food frequency questionnaire)

United Kingdom Women's Cohort

Vitamin D intake OTHER

(Estimated intake of vitamin D, derived from food frequency questionnaire and any recorded supplemental intake)

United Kingdom Women's Cohort

Eligibility Criteria

• Age: 36 Years - 69 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The UK Women's cohort profile is published here: https://doi.org/10.1093/ije/dyv173

You may qualify if:

• Female
• Ages 35 - 69 years at time of recruitment
• Able to provide informed consent

You may not qualify if:

• Male
• Not a resident of England
• Unable to link dietary and lifestyle data with hospital episode data
• Missing covariate data
• Rheumatoid arthritis records before or on the date of recruitment

Sponsors & Collaborators

• University of Leeds: lead

Study Sites (1)

University of Leeds Leeds

Leeds, West Yorkshire, LS2 9JT, United Kingdom

Location

Related Publications (1)

• Cade JE, Burley VJ, Alwan NA, Hutchinson J, Hancock N, Morris MA, Threapleton DE, Greenwood DC. Cohort Profile: The UK Women's Cohort Study (UKWCS). Int J Epidemiol. 2017 Apr 1;46(2):e11. doi: 10.1093/ije/dyv173. No abstract available.

  PMID: 26430789 BACKGROUND

Related Links

• Study website

MeSH Terms

Conditions

Arthritis, Rheumatoid; Alcohol Drinking; Arthritis

Interventions

Dietary Patterns; Ethanol; Fruit

Condition Hierarchy (Ancestors)

Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Autoimmune Diseases; Immune System Diseases; Drinking Behavior; Behavior

Intervention Hierarchy (Ancestors)

Diet; Nutritional Physiological Phenomena; Diet, Food, and Nutrition; Physiological Phenomena; Feeding Behavior; Alcohols; Organic Chemicals; Food; Food and Beverages

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Senior Lecturer in Biostatistics

Study Record Dates

• First Submitted: October 31, 2024
• First Posted: November 1, 2024
• Study Start: January 15, 1995
• Primary Completion: March 13, 2019
• Study Completion: March 13, 2019
• Last Updated: November 1, 2024

Record last verified: 2024-10

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, ICF
• Time Frame: The full data access policy for the UK Women's Cohort Study is available via the study website (https://ukwcs.leeds.ac.uk/).
• Access Criteria: The full data access policy for the UK Women's Cohort Study is available via the study website (https://ukwcs.leeds.ac.uk/).

Locations

GB (1)