NCT06664567

Brief Summary

In this registry-based cluster randomized controlled trial, we will assess the impact of a proactive strategy of general practitioners (GP) who will systematically provide screening kits of colorectal cancer (CRC) to all patients of even age (50, 52, 54...up to 74 years) versus usual practice where the eligible population receive an invitation letter to visit the general practitioner and receive the screening kit.

Trial Health

65
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
26,260

participants targeted

Target at P75+ for all trials

Timeline
17mo left

Started Jan 2026

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress29%
Jan 2026Jan 2028

First Submitted

Initial submission to the registry

October 28, 2024

Completed
1 day until next milestone

First Posted

Study publicly available on registry

October 29, 2024

Completed
1.2 years until next milestone

Study Start

First participant enrolled

January 1, 2026

Completed
2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2028

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2028

Last Updated

September 11, 2025

Status Verified

September 1, 2025

Enrollment Period

2 years

First QC Date

October 28, 2024

Last Update Submit

September 10, 2025

Conditions

Keywords

colorectal cancer screeninggeneral practitionersocial health inequalities

Outcome Measures

Primary Outcomes (1)

  • Participation rate in CRC screening

    The primary endpoint of this trial is the rate of participation rate in CRC screening in the eligible patient population grouped with or without intervention. This criterion will be measured by retrospective analysis of retrospective analysis of National Health Data System data.

    2 years after the start of protocol

Secondary Outcomes (3)

  • Positive test results

    2 years after the start of protocol

  • Positive test at an early stage

    2 years after the start of protocol

  • Positive test at a last stage

    2 years after the start of protocol

Study Arms (2)

Systematic provision of screening tests by GPs

The general practitioner systematically delivers the screening kit with justification and modalities of realization at an even age between 50 and 74 years to the patient who comes to consult for whatever reason, who is at intermediate risk of colorectal cancer and who falls under the generalized screening. The practitioner is helped in his approach by an initial training in the identification of the age, delivery of a poster, a study sheet, stickers and goodies, sending a quarterly letter on the progress of the study and contact with the coordination team.

Behavioral: Colorectal cancer screening test

Delivery of screening test according to GP's usual practice

the GP will issue the CRC screening kit in accordance with his/her usual practice.

Behavioral: Colorectal cancer screening test

Interventions

delivery of colorectal cancer screening test by GP

Delivery of screening test according to GP's usual practiceSystematic provision of screening tests by GPs

Eligibility Criteria

Age50 Years - 74 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Patient between 50 and 74 years old

You may qualify if:

  • \- medical practices in Aquitaine region and their visiting patients eligible for colorectal cancer screening individuals aged between 50 and 74 years at intermediate risk of colorectal cancer).

You may not qualify if:

  • medical practices with less than five individual eligible for colorectal cancer screening.
  • visiting patients aged less than 50 years or more than 74 years or at high or very high risk of colorectal cancer.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Colorectal Neoplasms

Condition Hierarchy (Ancestors)

Intestinal NeoplasmsGastrointestinal NeoplasmsDigestive System NeoplasmsNeoplasms by SiteNeoplasmsDigestive System DiseasesGastrointestinal DiseasesColonic DiseasesIntestinal DiseasesRectal Diseases

Central Study Contacts

Study Design

Study Type
observational
Observational Model
OTHER
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 28, 2024

First Posted

October 29, 2024

Study Start

January 1, 2026

Primary Completion (Estimated)

January 1, 2028

Study Completion (Estimated)

January 1, 2028

Last Updated

September 11, 2025

Record last verified: 2025-09