Effects of SIT Combined with Remote Ischemic Preconditioning on Vascular Function in Young Women with Masked Obesity

NCT06664281 | Completed

• 1 other identifier: ESITCRIPVFYWMO
• Study Type: interventional
• Target: 44
• Locations: 1 country
• Sites: 1

Brief Summary

Comparison of the effects of combined Sprint Interval Training (SIT) with Remote Ischemic Preconditioning (RIPC) and SIT on vascular function in young women with masked obesity.

Conditions

Vascular Function

Keywords

Sprint Interval Training; Masked Obesity; Young Women; Ischemic Preconditioning; Vascular Function

Outcome Measures

Primary Outcomes (2)

• Intima-Media Thickness (IMT)

  Changes in Intima media thickness before and after intervention.

  8 weeks

• Flow-Mediated Dilation (FMD)

  Changes in Flow-mediated dilation before and after Intervention. Brachial artery flow-mediated dilation (FMD) was measured by the UNEXEF high-resolution ultrasound vascular endothelial function analyzer.

  8 weeks

Secondary Outcomes (5)

• Body Composition Indicator

  8 weeks

• Human Morphometric i Indicators

  8 weeks

• Blood Pressure (BP)

  8 weeks

• Nitric Oxide (NO)

  8 weeks

• Maximum Oxygen Uptake (VO2max)

  8 weeks

Study Arms (3)

sprint interval training group

ACTIVE COMPARATOR

Behavioral: SIT

sprint interval training combined with remote ischemic preconditioning group

ACTIVE COMPARATOR

Behavioral: SIT combined RIPC

Control group

NO INTERVENTION

Interventions

SIT BEHAVIORAL

sprint interval training

sprint interval training group

SIT combined RIPC BEHAVIORAL

sprint interval training combined with remote ischemic preconditioning

sprint interval training combined with remote ischemic preconditioning group

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Females aged between 18 and 30 years;
• BMI within the normal range (18.5～24.9 kg/m²), BF% \> 30%;
• Participants with no clinically diagnosed contraindications for exercise, in good health, and not engaged in regular exercise, as determined by the health and physical activity questionnaire (based on the American College of Sports Medicine's guidelines for exercise testing and prescription).

You may not qualify if:

• History of cardiovascular diseases, including coronary heart disease, stroke, or peripheral arterial disease diagnosed through vascular imaging techniques;
• Currently participating in other intervention studies, including dietary, nutritional, or psychological education programs;
• Those with regular professional training;
• Musculoskeletal disorders that make long-term exercise interventions unsuitable.

Sponsors & Collaborators

• Beijing Sport University: lead

Study Sites (1)

School of Sports Medicine and Rehabilitation, Beijing Sport University

Beijing, China

Location

Related Publications (1)

• Ji Y, Yang L, Zhang P. Effects of sprint interval training combined with remote ischaemic preconditioning on vascular function in young women with masked obesity. Eur J Appl Physiol. 2025 Sep 22. doi: 10.1007/s00421-025-05970-4. Online ahead of print.

  PMID: 40982049 DERIVED

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 24, 2024
• First Posted: October 29, 2024
• Study Start: February 28, 2023
• Primary Completion: October 30, 2023
• Study Completion: December 30, 2023
• Last Updated: October 29, 2024

Record last verified: 2024-09

Locations

CN (1)