Erector Spinae Plane Block with Dexmedetomidine and Bupivacain Versus Dexamethasone and Bupivacain for Postoperative Analgesia in Patients Undergoing Abdominal Surgeries

NCT06658418 | Not Yet Recruiting Phase 1

• 1 other identifier: erector spinae plane block
• Study Type: interventional
• Target: 90
• Locations: 0 countries
• Sites: N/A

Brief Summary

To compare the analgesic effect of dexmedetomidine combined with bupivacaine versus dexamethasone combined with bupivacaine for ultrasound-guided ESPB for postoperative pain control in patients scheduled for abdominal surgeries

Conditions

Analgesia, Postoperative

Outcome Measures

Primary Outcomes (1)

• VAS score

  pain intensity using VAS score

  at 30 minutes, 2, 4, 6, 8, 12, 16, 20, and 24 hours postoperative.

Secondary Outcomes (1)

• the time for requirement of first morphine dose

  at 30 minutes, 2, 4, 6, 8, 12, 16, 20, and 24 hours postoperative.

Study Arms (2)

dexmedetomidine combined with bupivacaine

ACTIVE COMPARATOR

use for Dexmedetomidine and bupivacain for erector spinae plane block

Procedure: Erector Spinae Plane Block

dexamethasone combined with bupivacaine

EXPERIMENTAL

use of dexamethasone combined with bupivacaine for erector spinae plane block

Procedure: Erector Spinae Plane Block

Interventions

Erector Spinae Plane Block PROCEDURE

dexmedetomidine combined with bupivacaine versus dexamethasone combined with bupivacaine for ultrasound-guided ESPB for postoperative pain control in patients scheduled for abdominal surgeries.

dexamethasone combined with bupivacaine; dexmedetomidine combined with bupivacaine

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age :18 years old and older. Patients undergoing open abdominal surgery.

You may not qualify if:

• Patient refusal
• known sensitivity or contraindication to any of study drugs
• contraindications for local anesthesia
• Patients with local infection at site of puncture
• uncooperative patients
• history of psychological disorders or chronic pain and significant liver or renal disease.

Sponsors & Collaborators

• Loay Gamal: lead

Related Publications (1)

• Gottschalk A, Durieux ME, Nemergut EC. Intraoperative methadone improves postoperative pain control in patients undergoing complex spine surgery. Anesth Analg. 2011 Jan;112(1):218-23. doi: 10.1213/ANE.0b013e3181d8a095. Epub 2010 Apr 24.

  PMID: 20418538 BACKGROUND

MeSH Terms

Conditions

Agnosia

Condition Hierarchy (Ancestors)

Perceptual Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Central Study Contacts

loay GAMAL loay Gamal, master

CONTACT

+201017675686; loaygamal94@gmail.com

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, CARE PROVIDER
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: LGamal

Study Record Dates

• First Submitted: October 24, 2024
• First Posted: October 26, 2024
• Study Start: November 1, 2024
• Primary Completion (Estimated): November 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: October 26, 2024

Record last verified: 2024-10