Age-related Changes in Retinal Oxygen Extraction in Healthy Subjects

NCT06643403 | Recruiting

• 1 other identifier: OPHT-26052024
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

It has been found that several systemic and ocular diseases are associated with impaired retinal oxygen extraction. In the present study, retinal oxygen extraction will be measured in different age groups in order to identify age related changes in otherwise healthy subjects. In addition, the study will explore short-term changes in retinal metabolism induced by breathing pure oxygen. Measurements will be performed with dynamic vessel analyzer and laser speckle flowgraphy to evaluate retinal blood flow and retinal oxygen saturation, in order to calculate retinal oxygen extraction.

Conditions

Healthy Participants; Retinal Oxygen Extraction

Outcome Measures

Primary Outcomes (1)

• Retinal oxygen extraction in different age groups

  15 minutes

Study Arms (1)

Arm 1

EXPERIMENTAL

SAUERSTOFF medizinisch, Messer GmbH, Industriestrasse 5, 2352 Gumpoldskirchen, Austria Dose: min. 95.5%, breathing for max. 45 minutes

Drug: Oxygen 100% Gas for Inhalation

Interventions

Oxygen 100% Gas for Inhalation DRUG

SAUERSTOFF medizinisch, Messer GmbH, Industriestrasse 5, 2352 Gumpoldskirchen, Austria Dose: min. 95.5%, breathing for max. 45 minutes

Arm 1

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Men and women aged between 18 and 80 years
• Signed informed consent
• Normal ophthalmic findings, unless the investigator considers an abnormality to be clinically irrelevant for the purpose of the study
• Normal findings in the medical history, unless the investigator considers an abnormality to be clinically irrelevant for the purpose of the study
• Nonsmokers

You may not qualify if:

• Abuse of alcoholic beverages or drugs
• Participation in a clinical trial in the 3 weeks preceding the study
• Symptoms of a clinically relevant illness in the 3 weeks before the first study day
• Blood donation during the previous 3 weeks
• Pregnant or breast-feeding women

Sponsors & Collaborators

• Medical University of Vienna: lead

Study Sites (1)

Department of Clinical Pharmacology, Medical University of Vienna, Austria

Vienna, Vienna, 1090, Austria

RECRUITING

MeSH Terms

Interventions

Oxygen; Gases; Inhalation

Intervention Hierarchy (Ancestors)

Chalcogens; Elements; Inorganic Chemicals; Respiratory Mechanics; Respiration; Respiratory Physiological Phenomena; Circulatory and Respiratory Physiological Phenomena

Central Study Contacts

Doreen Schmidl-Schordje, MD

CONTACT

+43 1 40400; doreen.schmidl@meduniwien.ac.at

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assoc. Prof. Priv.-Doz. Dr.med.univ. PhD

Study Record Dates

• First Submitted: October 14, 2024
• First Posted: October 16, 2024
• Study Start: September 30, 2024
• Primary Completion: December 31, 2025
• Study Completion: January 31, 2026
• Last Updated: November 21, 2025

Record last verified: 2025-11

Locations

AU (1)