Influence of Fast and Slow Imagined Muscle Contractions on Muscle Function or Central Nervous System Properties

NCT06627491 | Recruiting

• 1 other identifier: MI_KA
• Study Type: interventional
• Target: 18
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this randomized clinical trial is to learn if imagining fast or slow muscle contractions causes different responses for nervous system excitability and muscle function in young, healthy males and females in. The main questions are: Does imagining fast muscle contractions cause greater nervous system excitability compared to imagining slow muscle contractions? Does imagining fast muscle contractions increase muscle function compared to imagining slow muscle contractions? A control condition (rest) will be compared with two intervention conditions: imagining fast and imagining slow conditions, to determine if the fast and slow increase outcomes more than control and if fast has the greatest response. Participants will:

• Attend 4 laboratory visits
• Perform 50 imagined contractions fast or slow, but with no physical movement
• Physical muscle contractions and non-invasive brain stimulation would be completed before and after each condition.

Conditions

Healthy

Keywords

Muscle strength; Nervous System; Motor Imagery

Outcome Measures

Primary Outcomes (2)

• Change in rate of torque development as measured by newton-meters per second

  A measure of the capacity to increase muscle torque rapidly as determined by the slope of the torque-time curve

  Baseline, minute 20

• Change in nervous system excitability as measured by electromyographic waveform aplitude following motor cortex stimulation

  A measure of excitability for the corticospinal tract

  Baseline, minute 20

Secondary Outcomes (5)

• Change in isometric bicep strength as measured by newton-meters of torque

  Baseline, minute 20

• Change in agonist muscle activation as measured by electromyography amplitude

  Baseline, minute 20

• Change in antagonist co-activation as measured by electromyography amplitude

  Baseline, minute 20

• Change in rate of agonist muscle activation as measured by electromyography amplitude

  Baseline, minute 20

• Change in nervous system inhibition as measured by electromyographic waveform aplitude following motor cortex stimulation

  Baseline, minute 20

Other Outcomes (2)

• Self-reported ability to imagine movements as measured by Movement Imagery Questionnaire-Revised as measured on a scale from 8 to 56

  Baseline

• Level of vividness for imagining the imagined contractions as measured by 7-point likert scale as measured from 1 to 7

  20 minutes after baseline

Study Arms (3)

Control

NO INTERVENTION

Participants will rest quietly with eyes closed during the control condition.

Fast

EXPERIMENTAL

Participants will imagine 2 blocks of 25 fast muscle contractions separated by 30 sec

Behavioral: Imagined muscle contractions

Slow

EXPERIMENTAL

Participants will imagine 2 blocks of 25 slow muscle contractions separated by 30 sec

Behavioral: Imagined muscle contractions

Interventions

Imagined muscle contractions BEHAVIORAL

The intervention involved imagining, with no physical movement, of muscle contractions.

Fast; Slow

Eligibility Criteria

• Age: 18 Years - 30 Years
• Gender Eligibility Details: male and female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Be between the ages of 18 - 30
• Healthy (no medical conditions)
• If female, must be taking the same monophasic oral contraceptive for the past 6 months
• Have a body mass index between 18.5 - 30 kg/m2
• Have not performed structured cardiovascular or resistance exercise in past 3 years
• Be right-handed
• Not currently taking stimulants, antipsychotic, anxiety, or depression medications
• Have not suffered an upper extremity musculoskeletal injury within the past year

You may not qualify if:

• If transcranial magnetic stimulation (TMS) is not deemed appropriate depending on your responses to the TMS-specific questionnaire
• Being ambidextrous
• Although rare, you will be excluded if discernable muscle activation responses are not possible via TMS

Sponsors & Collaborators

• Kennesaw State University: lead

Study Sites (1)

Kennesaw State University

Kennesaw, Georgia, 30144, United States

RECRUITING

MeSH Terms

Conditions

Neurologic Manifestations

Condition Hierarchy (Ancestors)

Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Garrett Hester, Ph.D.

CONTACT

470-578-4267; ghester4@kennesaw.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor of Exercise Science

Study Record Dates

• First Submitted: October 2, 2024
• First Posted: October 4, 2024
• Study Start: October 1, 2024
• Primary Completion: May 1, 2025
• Study Completion: May 1, 2025
• Last Updated: October 9, 2024

Record last verified: 2024-10

Data Sharing

• IPD Sharing: Will share
• Time Frame: Beginning 3 months and ending 5 years after the publication of results

Locations

US (1)