Predictive Value of Scoring System in Neonates with Disseminated Intravascular Coagulation

NCT06626880 | Not Yet Recruiting

• 1 other identifier: DIC scoring system in neonates
• Study Type: observational
• Target: 43
• Locations: 0 countries
• Sites: N/A

Brief Summary

The aims of this study were to investigate underlying diseases associated with neonatal DIC diagnosed on the first 28 days of life, and whether DIC score could predict mortality in neonates.

Conditions

Disseminated Intravascular Coagulation; Neonates

Outcome Measures

Primary Outcomes (2)

• The aims of this study were to investigate underlying diseases associated with neonatal DIC diagnosed on the first 28 days of life

  from 1/1/2025 to 1/1/2026.

• whether DIC score could predict mortality in neonates

  The aims of this study were to investigate underlying diseases associated with neonatal DIC diagnosed on the first 28 days of life, and whether DIC score could predict mortality in neonates.

  from 1/1/2025 to 1/1/2026.

Eligibility Criteria

• Age: Up to 28 Days
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Probability Sample

Study Population

The study will be conducted on neonates diagnosed as DIC based on their clinical and laboratory data. They will be recruited from NICU at Assiut University Children's Hospital from 1/1/2025 to 1/1/2026.

You may qualify if:

• age at enrollment from the first day of life to 28 days of life.
• Neonates diagnosed as DIC.

You may not qualify if:

• Neonates born to mothers with ITP.
• Autoimmune thrombocytopenic patients.

Sponsors & Collaborators

• Assiut University: lead

Related Publications (6)

• Veldman A, Fischer D, Nold MF, Wong FY. Disseminated intravascular coagulation in term and preterm neonates. Semin Thromb Hemost. 2010 Jun;36(4):419-28. doi: 10.1055/s-0030-1254050. Epub 2010 Jul 7.

  PMID: 20614393 BACKGROUND

• Shirahata A, Mimuro J, Takahashi H, Tsuji H, Kitajima I, Matsushita T, Eguchi Y, Kitamura N, Honda G, Sakata Y. Postmarketing Surveillance of Recombinant Human Soluble Thrombomodulin (Thrombomodulin alpha) in Pediatric Patients With Disseminated Intravascular Coagulation. Clin Appl Thromb Hemost. 2014 Jul;20(5):465-72. doi: 10.1177/1076029614523490. Epub 2014 Feb 20.

  PMID: 24563247 BACKGROUND

• Go H, Ohto H, Nollet KE, Kashiwabara N, Ogasawara K, Chishiki M, Hiruta S, Sakuma I, Kawasaki Y, Hosoya M. Risk factors and treatments for disseminated intravascular coagulation in neonates. Ital J Pediatr. 2020 Apr 29;46(1):54. doi: 10.1186/s13052-020-0815-7.

  PMID: 32349778 BACKGROUND

• Poralla C, Traut C, Hertfelder HJ, Oldenburg J, Bartmann P, Heep A. The coagulation system of extremely preterm infants: influence of perinatal risk factors on coagulation. J Perinatol. 2012 Nov;32(11):869-73. doi: 10.1038/jp.2011.182. Epub 2011 Dec 8.

  PMID: 22157628 BACKGROUND

• Tay SP, Cheong SK, Boo NY. Circulating tissue factor, tissue factor pathway inhibitor and D-dimer in umbilical cord blood of normal term neonates and adult plasma. Blood Coagul Fibrinolysis. 2003 Feb;14(2):125-9. doi: 10.1097/00001721-200302000-00002.

  PMID: 12632021 BACKGROUND

• Wada H, Matsumoto T, Yamashita Y. Diagnosis and treatment of disseminated intravascular coagulation (DIC) according to four DIC guidelines. J Intensive Care. 2014 Feb 20;2(1):15. doi: 10.1186/2052-0492-2-15. eCollection 2014.

  PMID: 25520831 BACKGROUND

MeSH Terms

Conditions

Disseminated Intravascular Coagulation

Condition Hierarchy (Ancestors)

Blood Coagulation Disorders; Hematologic Diseases; Hemic and Lymphatic Diseases; Hemorrhagic Disorders; Thrombophilia

Study Officials

• mohamed Hamdy Phd, Professor of hematology

  Professor of hematology of Pediatrics Faculty of Medicine - Assiut University

  STUDY CHAIR

• Amira Shalaby Assistant professor

  Assistant professor of neonatology Faculty of Medicine - Assiut University

  STUDY CHAIR

Central Study Contacts

Mohamed mostafa Sleem, Resident Doctor of pediatric

CONTACT

01558782966; Mohamed.16266163@med.aun.edu.eg

Mohamed Hamdy Ghazaly

CONTACT

01001296603; mohamed.ghazali@med.aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident Doctor of pediatric

Study Record Dates

• First Submitted: October 2, 2024
• First Posted: October 4, 2024
• Study Start: January 1, 2025
• Primary Completion: January 1, 2026
• Study Completion: March 29, 2026
• Last Updated: October 4, 2024

Record last verified: 2024-10