Exploring How Viral Infections Affect People With Chronic Lung Disease

NCT06625944 | Recruiting

• 2 other identifiers: 172663336487
• Study Type: observational
• Target: 180
• Locations: 1 country
• Sites: 1

Brief Summary

Many people with chronic lung disease have disease flare-ups. It was previously believed that these were mainly caused by bacteria but recent evidence suggests that viruses could be an important trigger. This study will recruit volunteers with chronic lung disease and take samples both when well (at baseline) and during flare-ups (exacerbations) to better understand the role of viruses in triggering exacerbations and also how the immune response is affected. The researchers will follow the volunteers\' progress for up to two years. Whenever they get unwell they will take some samples (nose swabs, finger prick testing, phlegm sample) and post them to the researchers. Then, they will come in for a visit for more samples (blood tests, further swabs) and a review.

Conditions

Bronchiectasis Adult; Bronchiectasis With Acute Exacerbation; COPD (Chronic Obstructive Pulmonary Disease); Respiratory Infection Virus

Keywords

Natural Cohort; Prospective; Bronchiectasis; Chronic Lung Disease; COPD

Outcome Measures

Primary Outcomes (1)

• Respiratory viruses detection during exaccerbations

  The percentage of chronic airway disease exacerbations where a respiratory virus is detected (with sub-classification of the specific viral subtypes).

  All exacerbations within a 24 month follow up period.

Secondary Outcomes (1)

• Differences in symptoms between viral and non-viral exacerbations

  All exacerbations within a 24 month follow up period.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with chronic lung disease under the care of respiratory teams at Royal Brompton and Harefield (NHS) Hospitals.

You may qualify if:

• Adults with a physician confirmed diagnosis of chronic airway disease (e.g. COPD and bronchiectasis) according to established diagnostic criteria.
• AND
• \- Prior history of exacerbation within last year (defined as requiring antibiotic and/or corticosteroids).

You may not qualify if:

• Inability to complete daily symptom diaries and/or attend for clinical assessments.
• Exacerbation within 4 weeks of study recruitment and/or clinical instability at the time of recruitment.
• Pregnancy.

Sponsors & Collaborators

• Imperial College London: lead

Study Sites (1)

Royal Brompton Hospital

London, United Kingdom

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Blood, Nasal Samples, Sputum, Stool

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive; Bronchiectasis

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Bronchial Diseases

Study Officials

• Anand Shah

  Imperial College London

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Patrick Senior

CONTACT

004402075895111; senior.patrick@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 1, 2024
• First Posted: October 3, 2024
• Study Start: November 1, 2024
• Primary Completion (Estimated): April 1, 2027
• Study Completion (Estimated): April 1, 2027
• Last Updated: July 14, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)