Effect of Endurance Training-Induced Coenzyme Q10 (CoQ10) Supplementation on Myokine, Exerkine Secretion and Cognitive Functions in Long-Distance Runners

NCT06619249 | Recruiting Phase 4

• 1 other identifier: AWFiS/2024_3_ZJ
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to learn if CoQ10 amplifies endurance training-induced myokine and exerkine secretion and if those changes influences cognition in long-distance runners. Does 4-week high-dosage CoQ10 supplementation increase the secretion of myokine, exerkine sercetion? Does the above-mentioned intervention improve the cognitive function in long distance runners? Participants will: Take CoQ10 or a placebo every day for 4 weeks. Visit the laboratory once every 4 weeks for checkups and tests. Keep the participants' food and training diary.

Conditions

Health Knowledge, Attitudes, Practice

Keywords

Coenzyme Q10; Supplementation; Myokine; Exerkine; Cognition; Long-distance runners

Outcome Measures

Primary Outcomes (2)

• Change in cognitive funtions as a result of CoQ10 supplementation measured via cogntitive function test.

  The investigators assume that supplementation with CoQ10 will change cognition (measured via cognitive function tests - Stroop Test, Trial Making Test A and Trial Making Test B) in long-distance runners. The results will be obtained as time (seconds) needed to complete tasks while testing.

  The investigators are going to check this hypothesis after 4 weeks of high-dose supplementation with CoQ10

• Change in myokine and exerkine concentration in the blood plasma as a result of CoQ10 supplementation.

  The investigators will assess the concentration of blood myokine and exerkine concentration (pg or ug/dl) of blood plasma using the colorimetric method.

  The investigators are going to check this hypothesis after 4 weeks of high-dose supplementation with CoQ10

Secondary Outcomes (1)

• Change in aerobic capacity measured via direct test to volitional exhaustion on a motorized treadmill

  The investigators are going to check this hypothesis after 4 weeks of high-dose supplementation with CoQ10

Study Arms (2)

CoQ10-treated participants

EXPERIMENTAL

The participants will be treated with CoQ10 supplements

Dietary Supplement: CoQ10 supplementation

Placebo-treated participants

PLACEBO COMPARATOR

The participants will be treated with placebo

Dietary Supplement: Placebo supplementation

Interventions

CoQ10 supplementation DIETARY_SUPPLEMENT

Long-distance runners will be supplemented with CoQ10 for 4 weeks in cross-over manner with 4 weeks of wash out period.

CoQ10-treated participants

Placebo supplementation DIETARY_SUPPLEMENT

Long-distance runners will be supplemented with placebo for 4 weeks in cross-over manner with 4 weeks of wash out period.

Placebo-treated participants

Eligibility Criteria

• Age: 30 Years - 50 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• training experienced for minimum 2 years
• running training at least 2 times per week
• Personal Best on 10k (\<50 minutes)

You may not qualify if:

• taking supplements which can interrupt primary outcomes (vitamin D, omega-3 fatty acids)
• injured in last 6 months to avoid n number reduction

Sponsors & Collaborators

• Gdansk University of Physical Education and Sport: lead

Study Sites (1)

Gdansk University of Physical Education and Sport

Gdansk, 80-333, Poland

RECRUITING

MeSH Terms

Conditions

Behavior

Study Design

• Study Type: interventional
• Phase: phase 4
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: A randomized, double-blind, placebo-controlled, cross-over study

Study Record Dates

• First Submitted: August 6, 2024
• First Posted: October 1, 2024
• Study Start: August 23, 2024
• Primary Completion: July 21, 2025
• Study Completion (Estimated): July 30, 2026
• Last Updated: August 26, 2025

Record last verified: 2024-08

Locations

PL (1)