Caffeine and Resistance Training in Older Adults

NCT06618261 | Active Not Recruiting

• 1 other identifier: CEIP/2022/3/055
• Study Type: interventional
• Target: 48
• Locations: 1 country
• Sites: 1

Brief Summary

Introduction: Several studies have evaluated and confirmed the ergogenic effect of acute caffeine intake on sports performance, specifically on strength and power performance. However, little is known about the prolonged effects of this supplement on neuromuscular adaptations to strength training. Objectives: The present study aims to analyze the effects of acute and chronic caffeine intake on neuromuscular adaptations to strength training, according to sex (men vs. women) and type of exercise (bench press vs. squat), as well as fatigue perception, mood state, and potential side effects in older adults.

Conditions

Caffeine and Resistance Training

Outcome Measures

Primary Outcomes (9)

• Mean velocity at different %1RM

  Measuring bar mean velocity desplacement during bench press and back squat exercises.

  Through study completion, an average of 12 weeks

• Peak velocity at different %1RM

  Measuring bar peak velocity and time to reach peak velocity of bar desplacement during bench press and back squat exercises.

  Through study completion, an average of 12 weeks

• Mean power output at different %1RM

  Measuring during bench press and back squat exercises.

  Through study completion, an average of 12 weeks

• Peak power output and time to reach peak power output at different %1RM

  Measuring during bench press and back squat exercises.

  Through study completion, an average of 12 weeks

• Number of repetitions performed at 65%1RM until task failure

  In bench press and back squat exercises

  Through study completion, an average of 12 weeks

• Bar velocity deplacement performed in 1 set at 65%1RM until task failure

  In bench press and back squat exercises

  Through study completion, an average of 12 weeks

• Power output generated in 1 set at 65%1RM until task failure

  In bench press and back squat exercise

  Through study completion, an average of 12 weeks

• Resting Metabolic Rate (RMR)

  Kcal at rest (RMR) using a metabolic chart.

  Through study completion, an average of 12 weeks

• Maximal Fat Oxidation Rate (MFO)

  g/min (MFO) using a metabolic chart.

  Through study completion, an average of 12 weeks

Secondary Outcomes (6)

• Fat mass

  Through study completion, an average of 12 weeks

• Fat-free mass

  Through study completion, an average of 12 weeks

• Physical activity (METs-min/wk)

  Through study completion, an average of 12 weeks

• Dietary (g/kg of macronutrients)

  Through study completion, an average of 12 weeks

• Mood state

  Through study completion, an average of 12 weeks

Study Arms (4)

Caffeine - Males

EXPERIMENTAL

Dietary Supplement: Caffeine + Resistance exercise

Placebo - Males

PLACEBO COMPARATOR

Dietary Supplement: Placebo + Resistance exercise

Caffeine - Females

EXPERIMENTAL

Dietary Supplement: Caffeine + Resistance exercise

Placebo - Females

PLACEBO COMPARATOR

Dietary Supplement: Placebo + Resistance exercise

Interventions

Caffeine + Resistance exercise DIETARY_SUPPLEMENT

Acute caffeine intake (3 mg/kg) prior each resistance training session of a 8 weeks training program.

Caffeine - Females; Caffeine - Males

Placebo + Resistance exercise DIETARY_SUPPLEMENT

Acute placeb intake (3 mg/kg of maltodextrin) prior each resistance training session of a 8 weeks training program.

Placebo - Females; Placebo - Males

Eligibility Criteria

• Age: 55 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age between ≥ 55
• Body mass index (BMI) ≥ 30 kg/m².
• Physically active subjects (\>150 min/week of moderate exercise).
• Healthy men and women without neurological, cardiometabolic, immunological, or physical conditions that prevent them from performing physical exercise.
• Participants capable of performing the tests.

You may not qualify if:

• History of neuromuscular, cardiac, or diseases that could affect liver or muscle metabolism.
• Use of drugs or other stimulants that interfere with caffeine intake and intestinal absorption during the tests and study.
• Having undergone prolonged periods of forced physical inactivity during the 6 months prior to the study.
• Performing strenuous exercise within 48 hours prior to the tests.
• Failing to replicate the same food intake on the two experimental days.
• Consuming caffeine after 6 PM on the day prior to training or testing.

Sponsors & Collaborators

• Alberto Pérez-López: lead
• University of Alcala: collaborator

Study Sites (1)

Facultad de Medicina y Ciencias de la Salud. Universidad de Alcalá

Alcalá de Henares, 28805, Spain

Location

MeSH Terms

Interventions

Caffeine

Intervention Hierarchy (Ancestors)

Xanthines; Alkaloids; Heterocyclic Compounds; Purinones; Purines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal Investigator

Model Details: Randomized controlled trial

Study Record Dates

• First Submitted: September 9, 2024
• First Posted: October 1, 2024
• Study Start: January 14, 2024
• Primary Completion (Estimated): July 30, 2026
• Study Completion (Estimated): July 30, 2026
• Last Updated: May 6, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will share

Locations

ES (1)