Caffeine and Resistance Training in Young Adults

NCT06610136 | Completed

• 1 other identifier: CEIP2021/6/138
• Study Type: interventional
• Target: 48
• Locations: 1 country
• Sites: 1

Brief Summary

Introduction: Several studies have evaluated and confirmed the ergogenic effect of acute caffeine intake on sports performance, specifically on strength and power performance. However, little is known about the prolonged effect of this supplement on neuromuscular adaptations to strength training. Introduction: Several studies have evaluated and confirmed the ergogenic effect of acute caffeine intake on sports performance, specifically on strength and power performance. However, little is known about the prolonged effects of this supplement on neuromuscular adaptations to strength training. Objectives: The present study aims to analyze the effects of acute and chronic caffeine intake on neuromuscular adaptations to strength training, according to sex (men vs. women) and type of exercise (bench press vs. squat), as well as on fatigue resistance during repeated sprints, fatigue perception, mood state, reaction time, diet, and potential side effects.

Conditions

Caffeine and Resistance Training

Outcome Measures

Primary Outcomes (7)

• Mean velocity at different %1RM

  Measuring bar mean velocity desplacement during bench press and back squat exercises.

  Through study completion, an average of 12 weeks

• Peak velocity at different %1RM

  Measuring bar peak velocity and time to reach peak velocity of bar desplacement during bench press and back squat exercises.

  Through study completion, an average of 12 weeks

• Mean power output at different %1RM

  Measuring during bench press and back squat exercises.

  Through study completion, an average of 12 weeks

• Peak power output and time to reach peak power output at different %1RM

  Measuring during bench press and back squat exercises.

  Through study completion, an average of 12 weeks

• Number of repetitions performed at 65%1RM until task failure

  In bench press and back squat exercises

  Through study completion, an average of 12 weeks

• Bar velocity deplacement performed in 1 set at 65%1RM until task failure

  In bench press and back squat exercises

  Through study completion, an average of 12 weeks

• Power output generated in 1 set at 65%1RM until task failure

  In bench press and back squat exercise

  Through study completion, an average of 12 weeks

Secondary Outcomes (8)

• Resting Metabolic Rate (RMR)

  Through study completion, an average of 12 weeks

• Maximal Fat Oxidation Rate (MFO)

  Through study completion, an average of 12 weeks

• Fat mass

  Through study completion, an average of 12 weeks

• Fat-free mass

  Through study completion, an average of 12 weeks

• Physical activity (METs-min/wk)

  Through study completion, an average of 12 weeks

Study Arms (4)

Caffeine - Males

EXPERIMENTAL

Dietary Supplement: Caffeine plus Resistance training

Placebo - Males

PLACEBO COMPARATOR

Other: Placebo + Resistance training

Caffeine - Females

EXPERIMENTAL

Dietary Supplement: Caffeine plus Resistance training

Placebo - Females

PLACEBO COMPARATOR

Other: Placebo + Resistance training

Interventions

Caffeine plus Resistance training DIETARY_SUPPLEMENT

Acute caffeine intake (3 mg/kg) prior each resistance training session of a 8 weeks training program.

Caffeine - Females; Caffeine - Males

Placebo + Resistance training OTHER

Acute placebo intake (3 mg/kg of maltodextrin) prior each resistance training session of a 8 weeks training program.

Placebo - Females; Placebo - Males

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age between ≥ 18 and ≤ 35 years.
• Body mass index (BMI) \< 25 kg/m².
• Physically active subjects (\>150 min/week of moderate exercise).
• Healthy men and women without neurological, cardiometabolic, immunological, or physical conditions that prevent them from performing physical exercise.
• Participants capable of performing the tests.

You may not qualify if:

• History of neuromuscular, cardiac, or diseases that could affect liver or muscle metabolism.
• Use of drugs or other stimulants that interfere with caffeine intake and intestinal absorption during the tests and study.
• Body mass index (BMI) \> 25 kg/m².
• Having undergone prolonged periods of forced physical inactivity during the 6 months prior to the study.
• Performing strenuous exercise within 48 hours prior to the tests.
• Failing to replicate the same food intake on the two experimental days.
• Consuming caffeine after 6 PM on the day prior to training or testing.

Sponsors & Collaborators

• University of Alcala: lead

Study Sites (1)

Facultad de Medicina y Ciencias de la Salud. Universidad de Alcalá

Alcalá de Henares, Madrid, 28805, Spain

Location

MeSH Terms

Interventions

Caffeine; Resistance Training

Intervention Hierarchy (Ancestors)

Xanthines; Alkaloids; Heterocyclic Compounds; Purinones; Purines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring; Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: Statistician
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: Randomized controlled trial

Study Record Dates

• First Submitted: September 9, 2024
• First Posted: September 24, 2024
• Study Start: January 15, 2023
• Primary Completion: May 30, 2024
• Study Completion: May 30, 2024
• Last Updated: September 24, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will share

Locations

ES (1)