Practical Ultrasonographic Detection of Sarcopenia in Patients With Long-term Gastrectomy

NCT06354348 | Completed

• 1 other identifier: GastrectomyUSG
• Study Type: interventional
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators aimed to evaluate long-term sarcopenia in patients with total and distal gastrectomy by measuring the anterior thigh muscle with USG, which is a more specific and easy method.

Conditions

Sarcopenia; Gastrectomy

Outcome Measures

Primary Outcomes (1)

• Sarcopenia (Sonographic thigh adjustment ratio (STAR) was calculated by dividing the anterior thigh muscle thickness (mm) by BMI )

  The diagnosis of sarcopenia was established if low muscle mass (i.e. STAR values \<1.4 for males and \<1.0 for females) was combined with low grip strength (\<32 kg (males) and \<19 kg (females)) and/or increased CST time (≥12 sec)

  through study completion, an average of 4 months

Study Arms (3)

Total gastrectomy

EXPERIMENTAL

Patients with esophagojejunostomy on endoscopic evaluation were considered as total gastrectomy.

Diagnostic Test: USG, Grip strength, Chair stand test (CST)

Distal gastrectomy

EXPERIMENTAL

Patients with resected mid-corpus with preserved corpus, fundus and cardia and gastrojejunostomy were considered as distal gastrectomy.

Diagnostic Test: USG, Grip strength, Chair stand test (CST)

No gastrectomy status

EXPERIMENTAL

Has not undergone a gastrectomy operation

Diagnostic Test: USG, Grip strength, Chair stand test (CST)

Interventions

USG, Grip strength, Chair stand test (CST) DIAGNOSTIC_TEST

Anterior thigh muscle thickness was measured with USG Grip strength was measured with an electronic hand dynamometer Chair stand test (CST) was performed while participants were asked to stand up and sit down from a chair - without arm rest, for five times as quick as possible, with their arms crossed over their chests.

Distal gastrectomy; No gastrectomy status; Total gastrectomy

Eligibility Criteria

• Age: 45 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Who agreed to participate in the study
• Total or subtotal gastrectomy at least 1 year ago

You may not qualify if:

• Rheumatic/neurological diseases
• Any organ failure,
• Limitation of mobility
• History of major orthopedic surgery,
• Chemotherapy programs
• Gastric carcinoma recurrence
• Parkinson's disease, previous stroke, cerebellar diseases, multiple sclerosis
• Major depression
• Those who use any assistive device for walking
• People with severe knee, hip and hand osteoarthritis
• Active malignancies (currently or within the last 1 year receiving radiotherapy/chemotherapy
• Severe chronic obstructive pulmonary disease
• Visual impairment and vestibular disorders
• Pregnancy

Sponsors & Collaborators

• Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital: lead

Study Sites (1)

Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital

Ankara, Turkey (Türkiye)

Location

Related Publications (4)

• Kara M, Kaymak B, Frontera W, Ata AM, Ricci V, Ekiz T, Chang KV, Han DS, Michail X, Quittan M, Lim JY, Bean JF, Franchignoni F, Ozcakar L. Diagnosing sarcopenia: Functional perspectives and a new algorithm from the ISarcoPRM. J Rehabil Med. 2021 Jun 21;53(6):jrm00209. doi: 10.2340/16501977-2851.

  PMID: 34121127 BACKGROUND

• Takahashi S, Shimizu S, Nagai S, Watanabe H, Nishitani Y, Kurisu Y. Characteristics of sarcopenia after distal gastrectomy in elderly patients. PLoS One. 2019 Sep 11;14(9):e0222412. doi: 10.1371/journal.pone.0222412. eCollection 2019.

  PMID: 31509590 BACKGROUND

• Okamoto A, Aikou S, Iwata R, Oya S, Kawasaki K, Okumura Y, Yagi K, Yamashita H, Nomura S, Seto Y. The type of gastrectomy affects skeletal muscle loss and the long-term outcomes of elderly patients with gastric cancer: a retrospective study using computed tomography images. Surg Today. 2022 May;52(5):812-821. doi: 10.1007/s00595-021-02414-2. Epub 2021 Nov 26.

  PMID: 34837102 BACKGROUND

• Kara M, Kaymak B, Ata AM, Ozkal O, Kara O, Baki A, Sengul Aycicek G, Topuz S, Karahan S, Soylu AR, Cakir B, Halil M, Ozcakar L. STAR-Sonographic Thigh Adjustment Ratio: A Golden Formula for the Diagnosis of Sarcopenia. Am J Phys Med Rehabil. 2020 Oct;99(10):902-908. doi: 10.1097/PHM.0000000000001439.

  PMID: 32941253 BACKGROUND

MeSH Terms

Conditions

Sarcopenia

Interventions

Hand Strength

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Muscle Strength; Physical Examination; Diagnostic Techniques and Procedures; Diagnosis; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: clinic physician

Study Record Dates

• First Submitted: March 30, 2024
• First Posted: April 9, 2024
• Study Start: December 6, 2023
• Primary Completion: March 30, 2024
• Study Completion: March 30, 2024
• Last Updated: April 9, 2024

Record last verified: 2024-04

Locations

TU (1)