NCT06605196

Brief Summary

The purpose of this study is to understand how to leverage structures and processes of academic health department (AHD) partnerships to facilitate implementation of cancer related evidence-based programs and policies (EBPPs).

Trial Health

63
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
364

participants targeted

Target at P75+ for not_applicable cancer

Timeline
26mo left

Started Apr 2026

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress1%
Apr 2026Jun 2028

First Submitted

Initial submission to the registry

December 6, 2023

Completed
10 months until next milestone

First Posted

Study publicly available on registry

September 20, 2024

Completed
1.6 years until next milestone

Study Start

First participant enrolled

April 30, 2026

Completed
2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 30, 2028

Expected
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

June 30, 2028

Last Updated

February 4, 2026

Status Verified

February 1, 2026

Enrollment Period

2 years

First QC Date

December 6, 2023

Last Update Submit

February 2, 2026

Conditions

Cancer

Keywords

Improving cancer prevention and controlacademic-local public health department partnerships

Outcome Measures

Primary Outcomes (2)

  • Evidence-Based Interventions

    Participants will see 5 questions about interventions related to specific public health program areas. They will be asked if their agency or institution has delivered those interventions within the last year. Possible score of 0 to 5. Higher score indicates a better outcome.

    Baseline, 2 years post baseline

  • Academic Health Department Evidence-Based Interventions

    Participants will see 5 questions about interventions related to specific public health program areas. They will be asked if their academic health department has delivered those interventions within the last year. Possible score of 0 to 5. Higher score indicates a better outcome.

    Baseline, 2 years post baseline

Secondary Outcomes (20)

  • Organizational Collaboration - Aligning strategy

    Baseline, 2 years post baseline

  • Organizational Collaboration - Coordinating Current Work

    Baseline, 2 years post baseline

  • Joint Decision Making

    Baseline, 2 years post baseline

  • Joint Operation

    Baseline, 2 years post baseline

  • Reduced Autonomy

    Baseline, 2 years post baseline

  • +15 more secondary outcomes

Study Arms (2)

Implementation Arm

EXPERIMENTAL

The implementation arm will receive tailored, guided support to improve their AHD partnerships.

Behavioral: Resources and guided facilitation

Control Arm

ACTIVE COMPARATOR

The control arm will be referred to existing resources in the Learning Community but will not receive new resources or guided facilitation.

Behavioral: Existing resources

Interventions

Resources and guided facilitationBEHAVIORAL

Participants in the intervention arm will participate in a planning period at the beginning of the intervention period to establish the goals for the partnership. The investigators will use the prioritized list of AHD partnership features developed in prior research to guide the initial planning period and then assist the partnership members to plan to implement the corresponding strategies focused on their areas of interest (e.g., developing collaborative projects, hiring faculty, staff, or students to conduct data analysis). The investigators will use telephone, email communication, and video conferencing to communicate with AHD partnerships, regularly assess progress towards goals, and adjust goals and strategies based on the progress. One additional in person visit to each AHD partnership in the intervention arm will be made in year 2 of implementation to review goals and progress and provide additional guidance and tailored support as needed.

Implementation Arm
Existing resourcesBEHAVIORAL

Individuals will be referred to existing resources in the Learning Community.

Control Arm

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Local health department practitioners who are involved in the implementation of cancer prevention and control programs within their communities and are engaged in an academic-health department partnership.
  • Employees in academic settings currently partnering with local health departments. These partnerships could be located anywhere within the United States.

You may not qualify if:

  • Individuals under the age of 18 years old.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Prevention Research Center at Washington University in St. Louis

St Louis, Missouri, 63130, United States

Location

Related Publications (1)

  • Mazzucca-Ragan S, Allen P, Amos K, Barker AR, Brewer M, Erwin PC, Gannon J, Gao F, Jacob RR, Lengnick-Hall R, Brownson RC. Improving cancer prevention and control through implementing academic-local public health department partnerships - protocol for a cluster-randomized implementation trial using a positive deviance approach. Implement Sci Commun. 2025 Feb 24;6(1):20. doi: 10.1186/s43058-025-00706-z.

    PMID: 39994666DERIVED

Related Links

MeSH Terms

Conditions

Neoplasms

Interventions

Health Resources

Intervention Hierarchy (Ancestors)

Health PlanningHealth Care Economics and OrganizationsDelivery of Health CareHealth Care Quality, Access, and Evaluation

Study Officials

  • Stephanie Mazzucca-Ragan

    Washington University School of Medicine

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Stephanie Mazzucca-Ragan

CONTACT

314-935-0117smazzucca@wustl.edu

Mary Adams

CONTACT

314-935-0115madams22@wustl.edu

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

December 6, 2023

First Posted

September 20, 2024

Study Start

April 30, 2026

Primary Completion (Estimated)

April 30, 2028

Study Completion (Estimated)

June 30, 2028

Last Updated

February 4, 2026

Record last verified: 2026-02

Data Sharing

IPD Sharing
Will share

Plan to share all IPD that underlie results in a publication.

Shared Documents
STUDY PROTOCOL, SAP, ICF, CSR, ANALYTIC CODE
Time Frame
Publications and underlying primary data generated as part of the proposed work will be shared. Publications will be made immediately available to the public without any embargo period.
Access Criteria
Electronic copies of publications will be deposited in PubMed Central using proper tagging of metadata to ensure online discoverability and accessibility within four weeks of acceptance by a journal. Underlying primary data (i.e., all survey- and qualitative data collected within grant activities) will be de-identified according to the Department of Health and Human Services (HHS) Regulations for the Protection of Human Subjects and Health Insurance Portability and Accountability Act (HIPAA) Privacy Rule and will be reviewed by our Institutional Review Board. De-identified data will be standardized and placed in a data repository that the investigators will develop for data sharing with a broader research community in a timely manner. The data repository will be updated upon publication of manuscripts. No limitations to the immediate and broad release of publication and underlying primary data are anticipated,

Locations

US(1)