Preoperative Prognostic Nutritional Index and Postoperative Delirium in Gastrointestinal Cancer Surgery

NCT06603129 | Completed

• 1 other identifier: 2021-10/1411
• Study Type: observational
• Target: 134
• Locations: 1 country
• Sites: 1

Brief Summary

Aim: We aimed to show the relationship between preoperative prognostic nutritional index and postoperative delirium in patients who had undergone gastrointestinal cancer surgery. Materials and Methods: Our study is a single-center, prospective, observational study. Routine preoperative anesthesia evaluation of all patients was performed and patient's age, sex, ASA physical score, body mass index (BMI), existing comorbid diseases, level of education, smoking status, cancer diagnosis, chemotherapy and radiotherapy history, type of surgery, past invasive interventions, concentration of hemoglobin and albumin, lymphocyte count, liver and kidney function tests were recorded. PNI score was calculated with the preoperative measurements. With the calculated PNI score, nutritional status was defined as normal (PNI ≥50), mild malnutrition (PNI 45-50), moderate-severe malnutrition (PNI 40-45), and severe (PNI \<40) accordingly. The patients were then evaluated for the presence of delirium using the Confusion Assessment Method (CAM) for 3 days postoperatively.

Conditions

Confusion Postoperative; Delirium; Gastrointestinal Cancer; Nutritional Deficiency

Keywords

confusion; delirium; gastrointestinal cancer; prognostic nutritional index

Outcome Measures

Primary Outcomes (1)

• Evaluation of the development of delirium

  Evaluation of whether delirium develops in postoperative patients within the first 3 days using the Confusion Assessment Method (CAM)

  15 October 2021-20 May 2022

Secondary Outcomes (3)

• demographic characteristics

  15 October 2021-15 June 2022

• amount of bleeding

  15 October 2021-15 June 2022

• biochemical parameters

  15 October 2021-15 June 2022

Study Arms (2)

Delirium Group

group that developed delirium within 3 days postoperatively

Diagnostic Test: prognostic nutritional index

Non Delirium Group

group that did not develop delirium within 3 days postoperatively

Diagnostic Test: prognostic nutritional index

Interventions

prognostic nutritional index DIAGNOSTIC_TEST

Prognostic nutritional index is an inflammation-based scoring that measures the nutritional and immunological status of patients and has been used to determine prognosis and predict postoperative complications.

Delirium Group; Non Delirium Group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

A total of 136 patients aged 18 years and older, who would undergo gastrointestinal cancer surgery and who could give voluntary consent, were included in the study.

You may qualify if:

• Patients aged 18 and over
• Patients who will undergo gastrointestinal cancer surgery
• Able to give voluntary consent
• ASA I-IV patients

You may not qualify if:

• Under 18 years old
• Those who do not agree to be included in the study
• Unconscious
• Hearing, sight and speech impaired
• Chronic alcohol user
• Patients with cognitive or psychiatric disorders such as known dementia, Parkinson's, Alzheimer's
• Patients who need postoperative mechanical ventilation support

Sponsors & Collaborators

• Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital: lead

Study Sites (1)

Muhammet Aydın Akdoğan

Ankara, 06220, Turkey (Türkiye)

Location

Related Publications (1)

• Liu H, Dai M, Guan H, Gao X, Zhou Y, Sun X, Zhou J, Hu X, Li X, Song Y, Han Y, Cao J. Preoperative Prognostic Nutritional Index Value is Related to Postoperative Delirium in Elderly Patients After Noncardiac Surgery: A Retrospective Cohort Study. Risk Manag Healthc Policy. 2021 Jan 6;14:1-8. doi: 10.2147/RMHP.S280567. eCollection 2021.

  PMID: 33442311 BACKGROUND

MeSH Terms

Conditions

Delirium; Gastrointestinal Neoplasms; Malnutrition; Confusion

Condition Hierarchy (Ancestors)

Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Neurocognitive Disorders; Mental Disorders; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Nutrition Disorders; Nutritional and Metabolic Diseases

Study Officials

• Gonca Oguz

  Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CROSSOVER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr.

Study Record Dates

• First Submitted: September 28, 2022
• First Posted: September 19, 2024
• Study Start: October 15, 2021
• Primary Completion: May 20, 2022
• Study Completion: June 15, 2022
• Last Updated: September 19, 2024

Record last verified: 2024-09

Locations

TU (1)