Oncology, Undernutrition and Sensoriality: Links, Mechanisms and Levers for Action

NCT06600295 | Recruiting

• 1 other identifier: COTTET INCa SHSESP 2023
• Study Type: observational
• Target: 306
• Locations: 1 country
• Sites: 1

Brief Summary

Cancers of the upper aerodigestive tract account for around 4% of all malignant tumours worldwide. Colon and liver cancer are the most common digestive cancers. The epidemiology of liver cancer is changing, and the number of deaths from liver cancer has increased by 25% worldwide (Huang 2022). In France, around 19,000 cancers of the upper aerodigestive tract and 88,000 new cases of digestive cancer are diagnosed each year (colon cancer remains the most common) (Globocan 2020). Patients with these two types of cancer are at particularly high risk of undernutrition (Pressoir 2010; Gyan 2018). In cancer patients, changes in diet may result from constraints linked to the cancer or possible after-effects, but also from personal choices (for example, adopting a healthier diet). Cancer and its treatment lead to changes such as increased nutritional requirements and hypercatabolism, or sensory changes (taste and smell), reducing pleasure and food intake. These problems will impair quality of life and intensify undernutrition, a major problem in the management of the disease since it increases the risk of complications, therapeutic failure and mortality. It is estimated that 10-20% of deaths in cancer patients are attributable to the consequences of undernutrition rather than to the disease itself (Pressoir 2010). In the VICAN study, 41% of patients changed their diet after diagnosis: 29% because of changes in taste and 82% to have a healthier diet (INCa 2014). These changes were associated with the treatment received, the presence of sequelae and anxiety. Taste and smell disorders are common in different types of cancer (any solid or haematological type) and treatments (chemotherapy, radiotherapy and surgery) (De Conno 1989; Heckel 2015; Spotten 2017; van Oort 2018). The mechanisms involved in sensory changes are not fully understood, especially in cancer, and with different types and treatments (Murtaza 2017). Several hypotheses have been proposed: altered expression of enzymes of the oral sphere, altered expression of sensory receptors (Neiers 2021), saliva composition and function (Zhu 2021), and impact of the oral microbiota (Schwartz 2021a, Licandro 2023). The early identification of undesirable effects linked to nutrition, and the early or anticipated diagnosis of undernutrition are important issues in the management of cancer patients. The pleasure (or displeasure) produced by food guides desire and eating behaviour. The mechanisms involved are linked to hedonic sensations: conditioned satiety, specific sensory satiety, negative alliesthesia and the reward system (hedonic system). The latter is influenced by the environment and can be consciously controlled, with several dimensions: liking (the patient likes or dislikes a given food) and wanting (evaluates the desire to consume a given food at a given moment). All these parameters, together with sensory and dietary learning throughout life (habits, beliefs and constraints), influence food preferences and therefore eating behaviour. Individual sensitivities and the personal history of the disease (treatment and care pathway, sequelae, presence of co-morbidities, etc.) must therefore be taken into account when setting up preventive actions for cancer patients. It seems important to explore these factors, the experience of patients and the consequences for eating behaviour in daily life, in order to improve support and communication with healthcare professionals, as well as prevention and early detection of undernutrition. It would be interesting to conduct more in-depth studies on nutritional status, quality of life and changes in taste and smell, which in most studies have been considered separately.

Conditions

Newly Diagnosed Cancer of the Oropharynx, Oral Cavity, Colon or Liver

Outcome Measures

Primary Outcomes (1)

• The presence or absence of undernutrition

  Through study completion, an average of 12 months

Study Arms (3)

patients with cancer of the oral cavity/oropharynx

115 patients with cancer of the oral cavity/oropharynx

Other: tests/questionnaires; Biological: biological samples; Other: evaluation

colon cancer patients

123 colon cancer patients

Other: tests/questionnaires; Biological: biological samples; Other: evaluation

patients with liver cancer

68 patients with liver cancer

Other: tests/questionnaires; Biological: biological samples; Other: evaluation

Interventions

evaluation OTHER

strength tests using handgrip tests, chair lifts or walking speed and sarcopenia tests for the over-70s

colon cancer patients; patients with cancer of the oral cavity/oropharynx; patients with liver cancer

tests/questionnaires OTHER

EVA, LFPQ-fr, Taste strips, ETOC 6-items, CiTAS, Fr-sQOD, WHOQOL-Bref, HADS

colon cancer patients; patients with cancer of the oral cavity/oropharynx; patients with liver cancer

biological samples BIOLOGICAL

blood, saliva, tongue mucus

colon cancer patients; patients with cancer of the oral cavity/oropharynx; patients with liver cancer

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Eligible patients will be identified : * at the department\'s multidisciplinary consultation meetings * during consultations with their referring doctor (ENT or gastroenterologist)

You may qualify if:

• Patient :
• With newly diagnosed cancer of the oropharynx, oral cavity, colon or liver (at any stage).
• For whom first-line treatment has been decided including radiotherapy, chemotherapy, immunotherapy and/or surgery.
• Able to follow all study procedures in accordance with the protocol.
• Have given their oral, free and informed consent to participate in the study.

You may not qualify if:

• Person not affiliated with national health insurance system
• Person subject to a legal protection measure (curatorship, guardianship)
• Pregnant women, women in labour or breastfeeding mothers
• Adults who is unable to give consent
• Minors
• Person unable to read, speak, write and understand French
• Patients with neuro-cognitive disorders (post-stroke, dyslexia, dyspraxia) or neuro-psychiatric disorders (dementia, autism) that make it impossible to assess taste sensoriality.
• Patients with olfactory or gustatory disorders documented prior to the disease
• Patient with another cancer currently being treated
• Patients with a systemic disease or physical trauma affecting taste perception
• Patients with kidney failure
• Patients with sinonasal polyposis
• Patients undergoing immunosuppressive treatment
• Patients with an estimated life expectancy of less than 3 months

Sponsors & Collaborators

• Centre Hospitalier Universitaire Dijon: lead

Study Sites (1)

Chu Dijon Bourgogne

Dijon, 21000, France

RECRUITING

MeSH Terms

Interventions

Surveys and Questionnaires

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Central Study Contacts

Vanessa COTTET

CONTACT

0380393487; Vanessa.cottet@u-bourgogne.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 13, 2024
• First Posted: September 19, 2024
• Study Start: September 6, 2024
• Primary Completion (Estimated): September 1, 2027
• Study Completion (Estimated): September 1, 2027
• Last Updated: February 19, 2026

Record last verified: 2026-02

Locations

FR (1)