Clinico-biological Collection of Bone, Calcium and Growth Plate Pathologies

NCT06444503 | Recruiting

• 1 other identifier: RC31/24/0214
• Study Type: observational
• Target: 350
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this project is to set up a biological and clinical collection of patients with progressive bone, calcium and growth plate pathologies. This collection will provide a better understanding of the mechanisms involved in growth plate and bone damage in these diseases and identify factors predictive of progression and new therapeutic targets.

Conditions

Bone Disorder

Outcome Measures

Primary Outcomes (1)

• Building a collection of biological samples and clinical-biological data from patients presenting bone, calcium and growth plate pathologies

  Blood and urine sampling

  Day 0 and through study completion, an average of 5 years

Secondary Outcomes (1)

• Identification of potential markers of disease progression based on new knowledge.

  Day 0 and through study completion, an average of 5 years

Study Arms (1)

Patients suffering from growth plate or bone pathology

As part of their pathology, patients benefit from clinical monitoring and regular blood and urine tests.

Other: Biological samples; Other: Biological

Interventions

Biological samples OTHER

Blood and urine will be taken in larger quantity

Patients suffering from growth plate or bone pathology

Biological OTHER

Surgical residues may be preserved in the event of surgery carried out as part of the treatment.

Patients suffering from growth plate or bone pathology

Eligibility Criteria

• Age: Up to 99 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with with growth plate or bone pathology.

You may qualify if:

• Children (from birth) with growth plate or bone pathology
• Patients affiliated to or benefiting from a social security scheme
• Patients able to receive information about the study and to understand the information form in order to participate in the study. This implies :
• mastery of the French language
• Not being subject to a restriction of rights by the judicial authorities
• Patients or legal representatives having given their consent to participate in the study (expression of non-opposition).

You may not qualify if:

• Patients under legal protection (guardianship, curatorship or safeguard of justice)
• Pregnant or breast-feeding women

Sponsors & Collaborators

• University Hospital, Toulouse: lead

Study Sites (1)

University Toulouse Hospital

Toulouse, 31000, France

RECRUITING

Biospecimen

Retention: SAMPLES WITHOUT DNA

Blood, urine, other body fluids and tissues biopsies

MeSH Terms

Conditions

Bone Diseases

Interventions

Biological Products

Condition Hierarchy (Ancestors)

Musculoskeletal Diseases

Intervention Hierarchy (Ancestors)

Complex Mixtures

Study Officials

• Thomas EDOUARD, MD

  University Hospital, Toulouse

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Thomas EDOUARD, MD

CONTACT

0534558555; edouard.t@chu-toulouse.fr

Sanaa EDDIRY

CONTACT

0561776110; eddiry.s@chu-toulouse.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 30, 2024
• First Posted: June 5, 2024
• Study Start: September 16, 2024
• Primary Completion (Estimated): September 16, 2034
• Study Completion (Estimated): September 16, 2034
• Last Updated: September 25, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)