Development and Validation of a Real-time Prediction Model for Acute Kidney Injury in Hospitalized Patients

NCT06597838 | Recruiting

• 1 other identifier: 2023[069-001]
• Study Type: observational
• Target: 161,876
• Locations: 1 country
• Sites: 1

Brief Summary

Early prediction of acute kidney injury (AKI) may provide a crucial opportunity for AKI prevention. To date, no prediction model targeting AKI among general hospitalized patients in developing countries has been published. We developed a simple, real-time, interpretable AKI prediction model for general hospitalized patients from a large tertiary hospital in China, and validated it across five independent, geographically distinct, different tiered hospitals.

Conditions

Prediction Model

Outcome Measures

Primary Outcomes (1)

• Predictive performance of the prediction model for Acute Kidney Injury

  Evaluated using AUC

  through study completion, varied from one to three years in different validation cohorts.

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adult patients admitted to five hospitals during the study period.

You may qualify if:

• Adult patients (18 years and older) admitted to five hospitals during the study period

You may not qualify if:

• Have less than 2 documented serum creatinine (Scr) measurements during hospitalization
• Being diagnosed with end-stage renal disease (ESRD)
• Maintained on dialysis or had an initial Scr greater than or equal to 4.0 mg/dL at admission
• Developed AKI prior to admission or within 24 hours after admission
• Length of stay shorter than 24 hours
• Underwent kidney transplantation or nephrectomy during hospitalization
• With all Scr measurements lower than or equal to 0.6 mg/dL from 90 days prior to admission until discharge.

Sponsors & Collaborators

• Peking University First Hospital: lead

Study Sites (1)

Peking University First Hospital

Beijing, Beijing Municipality, 100034, China

RECRUITING

Study Officials

• Li Yang

  Peking University First Hospital

  STUDY DIRECTOR

Central Study Contacts

Yuhui Zhang

CONTACT

+86 18813037026; 451076336@qq.com

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: September 9, 2024
• First Posted: September 19, 2024
• Study Start: February 28, 2023
• Primary Completion: October 30, 2024
• Study Completion: December 30, 2024
• Last Updated: September 19, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)