Prediction Models for Postoperative Reintubation in Patients With Acute Aortic Dissection

NCT06415630 | Completed

• 1 other identifier: WHUH-AADreintu
• Study Type: observational
• Target: 861
• Locations: 1 country
• Sites: 1

Brief Summary

Reintubation is an adverse postoperative complication in patients with Type A aortic dissection (AAD) that correlates to poor outcomes. This study aims to analyze the risk factors associated with reintubation and to create a fully automated score model to predict the incidence of reintubation. A total of 861 patients diagnosed with AAD and undergoing surgical procedures in a single institution between January 2018 and October 2023 were selected in wuhan Union Hospital. Preoperative and postoperative informmation was used for seeking risk factors and build prediction model for postoperative reintubation. Finally, 5 risk factors wasidentified and a nomogram was established for predicting postoperative reintubation in patients with AAD.

Conditions

Nomogram; Prediction Model; Type A Aortic Dissection; Postoperative Reintubation

Outcome Measures

Primary Outcomes (1)

• postoperative reintubation

  reintubation incidence in patients with type A aortic dissection undergoing surgery

  3 month

Study Arms (2)

training group

To determine potential predictive factors, the training group was subjected to LASSO regression analysis, which effectively eliminated several irrelevant or multicollinearity independent variables to reduce high-dimensional data.Seven models were initially constructed in the training group: multivariable logistics regression (MLR), decision-tree modeling, random forest, XGBoost, Support Vector Machines, k-nearest neighbors, and LightGBM.

Procedure: Type A aortic dissection surgery

testing group

Testing group was used to examine the performance of the seven prediction models, including discrimination and calibration performance. Finally, the model with best discrimination and calibration performance was used to construct nomogram for predicting reintubation.

Procedure: Type A aortic dissection surgery

Interventions

Type A aortic dissection surgery PROCEDURE

Patients with type A aortic dissection undergone surgery.

testing group; training group

Eligibility Criteria

• Age: 19 Years - 90 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

A total of 892 patients with AAD who underwent open surgery at Wuhan Union Hospital between January 2018 and October 2023 were enrolled using a convenient sampling method.

You may qualify if:

• (1) patients diagnosed with AAD admitted for open surgery; (2) aged 18 years or older.

You may not qualify if:

• (1) patients deceased during or within 24 hours after surgery; (2) patients with preoperative intubation.

Sponsors & Collaborators

• Union Hospital, Tongji Medical College, Huazhong University of Science and Technology: lead

Study Sites (1)

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Wuhan, Hubei, 430022, China

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 9, 2024
• First Posted: May 16, 2024
• Study Start: January 1, 2018
• Primary Completion: October 31, 2023
• Study Completion: December 31, 2023
• Last Updated: May 16, 2024

Record last verified: 2024-05

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)