Serum Uromodulin and DN Systematic Review and Meta Analysis

NCT06596863 | Completed DMC

• 1 other identifier: DKD serum uromodulin
• Study Type: observational
• Target: 1,774
• Locations: 1 country
• Sites: 1

Brief Summary

Several studies have investigated the association between the changes of serum uromodulin and diabetic nephropathy (DN). However, the results are still controversial. Hence, this meta-analysis aimed to evaluate the association of uromodulin with DN.

Conditions

Diabetic Nephropathies

Keywords

DKD, urimodulin

Outcome Measures

Primary Outcomes (1)

• Association of serum uromodulin with DKD: asystematic review and meta analysis

  Evaluate the meta analysis of association of serum uromodulin in the 3 diabetic group comparing with each other and compare them to the control group and correlate these results with other kidney biomarker

  may, 2024

Study Arms (2)

Control group

Included 862 healthy subjects as control group

Diagnostic Test: The association of serum uromodulin with DN; Diagnostic Test: The DN patients were divided according to the level of albumin to creatinine ratio (ACR), glomerular filtration rate (GFR), or albumin excretion rate (AER) in patients with DN

DKD group

Included 912 patients with DN

Diagnostic Test: The association of serum uromodulin with DN; Diagnostic Test: The DN patients were divided according to the level of albumin to creatinine ratio (ACR), glomerular filtration rate (GFR), or albumin excretion rate (AER) in patients with DN

Interventions

The association of serum uromodulin with DN DIAGNOSTIC_TEST

Meta analysis of association of serum uromodulin with DKD

Control group; DKD group

The DN patients were divided according to the level of albumin to creatinine ratio (ACR), glomerular filtration rate (GFR), or albumin excretion rate (AER) in patients with DN DIAGNOSTIC_TEST

DN patients were divided according to the level of albumin to creatinine ratio (ACR), glomerular filtration rate (GFR), or albumin excretion rate (AER) in patients with DN

Control group; DKD group

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The systematic search strategy retrieved 275 publications by the 4 databases (PubMed 76, Cochrane Library 11, Web of Science 107, and Scopus 81). 144 studies remained after exclusion the duplicates. After screening title and abstract 135 studies were excluded. 9 studies remained for full text and data reviewing. 4 studies of them were excluded as they didn't meet the eligibility criteria. In addition, 1 study was retrieved by manual search from Google Scholar. Finally, 6 articles were included \[20-25\]. The selected studies included 1774 participant

You may qualify if:

• Studies were included if they met the following criteria:
• serum level of uromodulin was determined;
• the samples were enrolled from diabetic patients;
• mean ± SD was reported for uromodulin between patients with and without DN;
• the level of albumin to creatinine ratio (ACR), glomerular filtration rate (GFR), or albumin excretion rate (AER) in patients with DN was determined

You may not qualify if:

• Studies were excluded according to the following criteria:
• duplicate studies;
• review articles;
• non original research articles;
• studies with insufficient data to extract;
• non-human research;
• studies that determined urine level of uromodulin.

Sponsors & Collaborators

• Tanta University: lead
• Ain Shams University: collaborator

Study Sites (1)

Tanta Yniversity

Tanta, Yes, 31511, Egypt

Location

MeSH Terms

Conditions

Diabetic Nephropathies

Interventions

Glomerular Filtration Rate

Condition Hierarchy (Ancestors)

Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Diabetes Complications; Diabetes Mellitus; Endocrine System Diseases

Intervention Hierarchy (Ancestors)

Kidney Function Tests; Diagnostic Techniques, Urological; Diagnostic Techniques and Procedures; Diagnosis; Urinary Tract Physiological Phenomena; Reproductive and Urinary Physiological Phenomena

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr of Biochemistry

Study Record Dates

• First Submitted: September 11, 2024
• First Posted: September 19, 2024
• Study Start: May 1, 2024
• Primary Completion: May 30, 2024
• Study Completion: May 30, 2024
• Last Updated: September 19, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)