Comparison of IV Nalbuphine Versus Ibuprofen for Postoperative Pain Control in Cesarean Section

NCT06594224 | Completed

• 1 other identifier: NishterMultan-1
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 2

Brief Summary

The local data is insufficient to directly compare IV nalbuphine versus ibuprofen among people in this region. The findings of this study would add to the existing data and would be helpful for health providers to opt for a better option for postoperative pain relief following a cesarean section under general anesthesia.

Conditions

Pain Management

Outcome Measures

Primary Outcomes (1)

• Efficacy in pain control

  Outcome was noted in the form of VAS pain scores. Scores from 1 to 3 were labeled as mild pain, 4 to 6 as moderate pain, and 7 to 10 as severe pain.

  At 1 hour, 3 hours, and 6 hours.

Study Arms (2)

IV Ibuprofen Group

EXPERIMENTAL

Females in this group (n=40) were given 800 mg Ibuprofen in 200 cc normal saline intravenously at the time of arrival in the ward

Drug: Ibuprofen

IV Nalbuphine

EXPERIMENTAL

Patients in this group received 20 mg nalbuphine in 200 cc normal saline IV at the time of arrival in the ward.

Drug: Nalbuphine

Interventions

Ibuprofen DRUG

Patients were given 800 mg Ibuprofen in 200 cc normal saline intravenously at the time of arrival in the ward.

IV Ibuprofen Group

Nalbuphine DRUG

Patients received 20 mg nalbuphine in 200 cc normal saline IV at the time of arrival in the ward.

IV Nalbuphine

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Parturient females
• Aged between 18-45 years
• Gestational age above 32 weeks
• ASA class I to II
• Anticipated hospital stay for at least 24 hours

You may not qualify if:

• Known allergy to the drugs being evaluated in this study
• Renal and/or hepatic impairment (as per medical record)
• History of bronchial asthma or history or risk of intracranial hemorrhage (as per medical record)
• Low platelets count (\<70000) or with bleeding diathesis
• BMI above 30 kg/m2

Sponsors & Collaborators

• Muhammad Aamir Latif: lead

Study Sites (2)

Nishtar Hospital

Multan, Punjab Province, 66000, Pakistan

Location

Nishtar Medical University

Multan, Punjab Province, 66000, Pakistan

Location

Related Publications (1)

• Khakwani M, Parveen R, Sultana H. Comparison of IV Nalbuphine versus ibuprofen for Postoperative Pain control in cesarean section. Pak J Med Sci. 2025 Sep;41(9):2612-2617. doi: 10.12669/pjms.41.9.11016.

  PMID: 41070313 DERIVED

MeSH Terms

Conditions

Agnosia

Interventions

Ibuprofen; Nalbuphine

Condition Hierarchy (Ancestors)

Perceptual Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Phenylpropionates; Acids, Carbocyclic; Carboxylic Acids; Organic Chemicals; Morphinans; Opiate Alkaloids; Alkaloids; Heterocyclic Compounds; Heterocyclic Compounds, Bridged-Ring; Heterocyclic Compounds, 4 or More Rings; Heterocyclic Compounds, Fused-Ring; Phenanthrenes; Polycyclic Aromatic Hydrocarbons; Polycyclic Compounds

Study Officials

• Mehnaz Khakwani, FCPS

  Department of Obstetric and Gynecology Nishtar Medical University, Multan

  PRINCIPAL INVESTIGATOR

• Hajra Sultana, FCPS

  Department of Obstetric and Gynecology Nishtar Medical University, Multan

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: RESnTEC, Institute of Research

Study Record Dates

• First Submitted: September 9, 2024
• First Posted: September 19, 2024
• Study Start: March 1, 2024
• Primary Completion: August 31, 2024
• Study Completion: August 31, 2024
• Last Updated: September 19, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will not share

Locations

PA (2)