Comparison of the Clinical and Microbiological Effects of CHX and HOCl Containing Mouthwashes
1 other identifier
interventional
26
1 country
1
Brief Summary
The primary objective of the study is to compare the antiplaque and anti-inflammatory effects of HOCl mouth rinse with those of CHX mouth rinse. The secondary objective is to evaluate and compare the antimicrobial activities of HOCl mouth rinse and CHX mouth rinse on dental biofilm.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Mar 2021
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 15, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 26, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
September 30, 2022
CompletedFirst Submitted
Initial submission to the registry
August 29, 2024
CompletedFirst Posted
Study publicly available on registry
September 19, 2024
CompletedSeptember 19, 2024
September 1, 2024
1.4 years
August 29, 2024
September 5, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
plaque index
Plaque index results were evaluated regionally and full mouth for CHX and HOCl groups.
1 month
Secondary Outcomes (1)
microbiology
1 month
Study Arms (2)
HOCl
EXPERIMENTALCHX
ACTIVE COMPARATORInterventions
Eligibility Criteria
You may qualify if:
- Being systematically healthy
- Having at least 22 natural teeth (236)
- Not smoking
- Participants must not drink alcohol and must work during their term
You may not qualify if:
- Having periodontitis and gingivitis
- Being breastfeeding or pregnant
- Using medication that may affect periodontal status
- Having used antibiotics in the last month
- Having used any mouthwash in the last month
- Using fixed, removable dentures or orthodontic appliances
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Baskent University Faculty of Dentistry
Ankara, 06000, Turkey (Türkiye)
Related Publications (1)
Lafaurie GI, Zaror C, Diaz-Baez D, Castillo DM, De Avila J, Trujillo TG, Calderon-Mendoza J. Evaluation of substantivity of hypochlorous acid as an antiplaque agent: A randomized controlled trial. Int J Dent Hyg. 2018 Nov;16(4):527-534. doi: 10.1111/idh.12342. Epub 2018 Apr 2.
PMID: 29608039BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Mehtap Bilgin Cetin, Assoc. prof.
Başkent Üniversitesi
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- PREVENTION
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Director
Study Record Dates
First Submitted
August 29, 2024
First Posted
September 19, 2024
Study Start
March 15, 2021
Primary Completion
August 26, 2022
Study Completion
September 30, 2022
Last Updated
September 19, 2024
Record last verified: 2024-09