Changes in Renal Perfusion During Hemodialysis in Patients with End-stage Renal Disease

NCT06587997 | Not Yet Recruiting

• 1 other identifier: HD-RPC
• Study Type: observational
• Target: 20
• Locations: 0 countries
• Sites: N/A

Brief Summary

Residual renal function (RRF) characteristically declines after patients with end-stage renal disease (ESRD) initiate dialysis. Although RRF preservation correlates with improved patient\'s quality of life and survival prospects, poor understanding of the pathophysiology underlying RRF decline limits protection strategies.

Conditions

End-stage Renal Disease

Keywords

hemodialysis; renal perfusion; end-stage renal disease

Outcome Measures

Primary Outcomes (1)

• renal perfusion

  Changes in renal perfusion during hemodialysis in patients with end-stage renal disease

  one day

Secondary Outcomes (3)

• diastolic blood pressure

  one day

• systolic blood pressure

  one day

• urine volume

  10 months

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

First Medical Center of Chinese PLA General Hospital

You may qualify if:

• Age ≥ 18 years;
• Clinical diagnosis of end-stage renal disease requiring long-term hemodialysis treatment, with dialysis duration ≤ 3 months;
• Urine output \> 500ml/day or GFR \> 3ml/min/1.72m2;
• Signed and dated informed consented is obtained.

You may not qualify if:

• Presence of vascular access dysfunction (blood flow rate \< 180ml/min);
• Severe heart failure;
• Active infection;
• Infectious disease;
• Patients with severe anemia;
• Patients with polycystic kidney disease;
• Expected dialysis duration \< 6 months;
• Pregnancy or lactation women;
• Patients who are participating in other clinical studies, or who have participated in other clinical studies within 3 months prior to enrollment;
• Unwillingness to be followed up or poor adherence to treatment;
• Other circumstances that the investigator considers unsuitable for enrolment.

Sponsors & Collaborators

• Yuanjun Yang: lead

MeSH Terms

Conditions

Kidney Failure, Chronic

Condition Hierarchy (Ancestors)

Renal Insufficiency, Chronic; Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Dayang Xie

CONTACT

13718941415; 460436948@qq.com

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Target Duration: 10 Months
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Director

Study Record Dates

• First Submitted: September 5, 2024
• First Posted: September 19, 2024
• Study Start: September 5, 2024
• Primary Completion (Estimated): September 3, 2026
• Study Completion (Estimated): September 3, 2026
• Last Updated: September 19, 2024

Record last verified: 2024-09