Testicular Function and Semen Quality in Male Childhood and Adolescent Cancer Survivors

NCT06587477 | Recruiting

• 1 other identifier: UW21-038
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

Cancer treatment can affect the testicular function, including sperm and hormonal functions. The aim of this study is to assess the testicular function and semen quality in young men who recover from childhood and adolescent cancer in Hong Kong. This can provide more information for pre-treatment counselling as well as improve post treatment survivorship care. The testicular function will be compared to aged-matched controls from men attending the Family Planning Association for premarital check-up.

Conditions

Cancer, Treatment-Related; Late Effect; Semen Analysis

Keywords

cancer treatment; testicular function; semen quality; cancer survivors

Outcome Measures

Primary Outcomes (1)

• Sperm concentration

  Sperm concentration

  up to 3 months

Secondary Outcomes (1)

• Semen parameters

  up to 3 months

Other Outcomes (2)

• Testicular volume

  up to 3 months

• Hormonal profile

  up to 3 months

Study Arms (2)

Male childhood and adolescent cancer survivors

Male childhood and adolescent cancer survivors

Other: Hormonal profile; Other: Semen analysis; Other: Questionnaire

Controls

Aged-matched controls from men attending the Family Planning Association for premarital check-up

Other: Hormonal profile; Other: Semen analysis; Other: Questionnaire

Interventions

Hormonal profile OTHER

Blood for FSH, LH, testosterone

Controls; Male childhood and adolescent cancer survivors

Semen analysis OTHER

Semen analysis

Controls; Male childhood and adolescent cancer survivors

Questionnaire OTHER

The European Male Ageing Study (EMAS) questionnaire

Controls; Male childhood and adolescent cancer survivors

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: male
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Target participant Population * The target population for the trial will be men who have received chemotherapy and/ or radiotherapy for cancer diagnosed when they were \< 18 years old. * Aged-matched controls from men attending the Family Planning Association for premarital check-up

You may qualify if:

• Men who have received chemotherapy and/ or radiotherapy for cancer diagnosed when they were \< 18 years old.
• \> 18 years old to 50 years old
• Cancer in remission for at least 2 years

You may not qualify if:

• Unable to ejaculate by masturbation to provide semen samples
• Cryptorchidism, testicular cancer, history of vasectomy
• On testosterone replacement therapy
• Refusal to join the study

Sponsors & Collaborators

• The University of Hong Kong: lead
• Queen Mary Hospital, Hong Kong: collaborator
• Prince of Wales Hospital, Shatin, Hong Kong: collaborator
• Hong Kong Children's Hospital: collaborator

Study Sites (1)

Queen Mary Hospital

Hong Kong, China

RECRUITING

Biospecimen

Retention: SAMPLES WITHOUT DNA

Excess serum for future research use

MeSH Terms

Conditions

Neoplasms, Second Primary

Interventions

Semen Analysis; Surveys and Questionnaires

Condition Hierarchy (Ancestors)

Neoplasms

Intervention Hierarchy (Ancestors)

Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Investigative Techniques; Data Collection; Epidemiologic Methods; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Central Study Contacts

Jennifer Ko

CONTACT

22554647; jenko@hku.hk

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Target Duration: 3 Weeks
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 13, 2024
• First Posted: September 19, 2024
• Study Start: January 16, 2023
• Primary Completion (Estimated): December 31, 2027
• Study Completion (Estimated): June 30, 2028
• Last Updated: September 19, 2024

Record last verified: 2024-05

Locations

CN (1)