Effects of UC-II, Glucosamine and Curcumin Supplementation on Knee Pain and Inflammation.

NCT06581094 | Completed Results

• 1 other identifier: N202406039
• Study Type: interventional
• Target: 32
• Locations: 1 country
• Sites: 1

Brief Summary

This research evaluated the effects of UCII, glucosamine and curcumin supplementation on knee pain and inflammation.

Conditions

Inflammation; Knee Pain Chronic

Keywords

Non-denatured type II collagen; Glucosamine; Curcumin; Knee Pain

Outcome Measures

Primary Outcomes (5)

• Points Change of Pain Evaluation Scale

  Self-assess pain using a visual analog scale (VAS), which is a straight line 10 cm in length, with 0 cm on the left representing no pain and 10 cm on the right representing extreme pain. Explain to the subjects that the pain intensity increases from left to right. Ask the subjects to mark the point on the line that corresponds to their pain level, and then record the distance in centimeters from the 0 cm mark. Record the points that the subjects wrote.

  baseline, week 6, week 12

• Time Change of Up-and-go Test

  Timed up-and-go test (TUG) was a professional physical therapist marked a distance of 3 meters on the ground and placed an armless chair at one end. The subject sat on the chair with a straight back, and the time was measured from when the subject stood up and walked to the 3-meter mark at their usual speed, turned around, walked back, and sat down again. Shorter time spent indicates better knee function. Record the time that the subjects spent.

  baseline, week 6, week 12

• Degrees Change of Range of Motion (ROM)

  A professional physical therapist tested the active flexion and extension of the knee joint (range of motion, ROM) as the subjects attempted to achieve maximum active flexion and extension. Record the angle that the physical therapist measured. AROM: active range of motion; PROM: passive range of motion

  baseline, week 6, week 12

• Points Change of Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)

  Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), a widely used questionnaires used by health professionals to evaluate the condition of patients with osteoarthritis of the knee and hip, and the total score was 96 points (Minimum: 0 points; Maximum: 96 points). The question content was divided into three parts: Pain (20 points), Stiffness (8 points), and Physical function (68 points). The higher score meant worse knee joint function. Record the points that the subjects got.

  baseline, week 6, week 12

• The Concentration of Serum Inflammatory Factors

  The concentration of interleukin-6 (IL-6), interleukin-1 beta (IL-1β), and tumor necrosis factor alpha (TNF-α) in serum.

  baseline, week 6, week 12

Study Arms (2)

Control group

PLACEBO COMPARATOR

Control group use 42 mg UCII.

Dietary Supplement: Placebo

Test group (UCII, glucosamine, and curcumin)

EXPERIMENTAL

Test group use 42 mg UCII, 460 mg glucosamine and 380 mg curcumin

Dietary Supplement: UCII, glucosamine and curcumin

Interventions

UCII, glucosamine and curcumin DIETARY_SUPPLEMENT

compound capsules twice daily.

Test group (UCII, glucosamine, and curcumin)

Placebo DIETARY_SUPPLEMENT

Placebo capsules twice daily.

Control group

Eligibility Criteria

• Age: 20 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Knee plain

You may not qualify if:

• Severe diseases of the heart, liver, kidneys, endocrine system, and other organs
• Long-term use of medication
• Infection, hypertension, diabetes, cerebrovascular disease, heart disease, liver disease, kidney disease, gastrointestinal disease
• Allergy to this product

Sponsors & Collaborators

• Taipei Medical University: lead

Study Sites (1)

Taipei medical university

Taipei, Taiwan

Location

MeSH Terms

Conditions

Inflammation

Interventions

Glucosamine; Curcumin

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Hexosamines; Amino Sugars; Carbohydrates; Diarylheptanoids; Heptanes; Alkanes; Hydrocarbons, Acyclic; Hydrocarbons; Organic Chemicals; Catechols; Phenols; Benzene Derivatives; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic

Results Point of Contact

• Title: YiWen Chien, PhD
• Organization: Taipei medical university

ychien@tmu.edu.tw

02-2736-1661

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, CARE PROVIDER
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 29, 2024
• First Posted: September 3, 2024
• Study Start: August 20, 2024
• Primary Completion: November 14, 2024
• Study Completion: December 3, 2024
• Last Updated: January 7, 2026
• Results First Posted: January 7, 2026

Record last verified: 2024-07

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)