Viscoelastic Properties of Respiratory and Peripheral Muscles of COPD Patients

NCT06580353 | Completed

• 1 other identifier: 2023/391
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study was to compare the viscoelastic properties of auxiliary respiratory muscles and peripheral muscles of chronic obstructive pulmonary disease patients with healthy subjects. Myotonometry was used to evaluate the viscoelastic properties of the muscles. The viscoelastic properties of the sternoclaidus mastoid, pectoralis major, upper trapezius, deltoid, biceps brachii, rectus femoris, gastrocinemius, and tibialis anterior muscles were evaluated.

Conditions

COPD; Muscle Tone Abnormalities

Outcome Measures

Primary Outcomes (7)

• Respiratory functions (PEF)

  Peak expiratory flow (PEF) were measured was evaluated with spirometry. It will be recorded as liters and expected percentage

  1 Day

• The Medical Research Council Scale

  Patients simply indicate on the scale the level of activity that causes dyspnoea in them according to the activities between 0-4.

  1 Day

• The COPD Assessment Test

  This statement describes a scale consisting of eight items, each with response values ranging from 0 to 5. The total score is calculated by summing the responses to all the items, resulting in a range from 0 to 40. A higher total score indicates a greater negative impact of the disease on the individual's quality of life and daily activities.

  1 Day

• Viscoelastic properties of muscles

  The viscoelastic properties of the muscles (muscle tone (Hz), and elasticity (Relative), stiffness (N/m)) were measured using a hand-held myotonometer.

  1 Day

• Respiratory functions (FEV1)

  In pulmonary function test was evaluated with spirometry. forced expiratory volume in the first second (FEV1);will be recorded as liters and expected percentage

  1 Day

• Respiratory functions (FVC)

  In pulmonary function test was evaluated with spirometry. forced expiratory volume in the first second (FEV1);will be recorded as liters and expected percentage

  1 Day

• Respiratory functions (FEV1/FVC)

  ratio of forced expiratory volume in the first second to vital capacity (FEV1/FVC) was evaluated with spirometry.

  1 Day

Study Arms (2)

COPD group

Patients with COPD who presented to the chest diseases polyclinic and whose symptoms of cough, sputum and/or dyspnoea accompanied by tachypnoea and/or tachycardia had not worsened in the last 14 days were defined as 'Stable COPD group' \[

Control group

The control group was defined as those who did not have any systemic disease and who were normal at the end of the polyclinic examination who applied to the chest diseases polyclinic.

Eligibility Criteria

• Age: 40 Years+
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with COPD who visited the chest diseases clinic and had symptoms of cough, sputum, and/or shortness of breath, along with tachypnea and/or tachycardia, that had not worsened in the past 14 days were classified as the 'Stable COPD group'.

You may qualify if:

• male gender,
• body mass index (BMI) between 18.5-29.9 kg/m2,
• stable COPD patients

You may not qualify if:

• being in the acute exacerbation period for COPD patients,
• having undergone any neurological, orthopaedic or thoracic surgery,
• presence of malignancy in any organ,
• presence of comorbidities affecting muscle atrophy (myasthenia gravis, muscular dystrophy, etc.).

Sponsors & Collaborators

• Gaziantep Islam Science and Technology University: lead

Study Sites (1)

Gaziantep İslamic Science and Technology University

Gaziantep, Şahinbey, 27000, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant professor

Study Record Dates

• First Submitted: August 26, 2024
• First Posted: August 30, 2024
• Study Start: January 1, 2024
• Primary Completion: April 1, 2024
• Study Completion: May 1, 2024
• Last Updated: November 22, 2024

Record last verified: 2024-01

Locations

TU (1)