Effects of Core Stabilization and Inspiratory Muscle Training in Patients With COPD

NCT06510686 | Completed

• 1 other identifier: 2024-183
• Study Type: interventional
• Target: 36
• Locations: 1 country
• Sites: 1

Brief Summary

In Chronic Obstructive Pulmonary Disease (COPD), a mismatch develops between the respiratory system's demand and the functional capacity of respiratory muscles due to the combination of local and systemic factors increasing the respiratory workload. This results in impaired coordination of muscle groups, leading to muscle dysfunction. Respiratory muscle dysfunction is a significant determinant of life expectancy in COPD. Additionally, respiratory muscles unable to cope with increased workloads lead to impaired respiratory functions and reduced exercise capacity. It is widely accepted that appropriate training of respiratory muscles can increase their strength, endurance, and their close relationship with lung volume capacities. Besides their role in respiration, respiratory muscles also contribute to postural function and core stabilization. Studies on respiratory muscle training in COPD have primarily focused on inspiratory muscle strength training, neglecting the core stabilization function of respiratory muscles. However, optimal gains in a muscle can only be achieved with training tailored to its functional characteristics. Therefore, a comprehensive training program should be developed considering the multifunctional nature of respiratory muscles. Studies published in healthy individuals and different patient populations demonstrate that core training can improve lung functions. The aim of this study is to compare the effects of inspiratory muscle training and core stabilization training on diaphragm activation, inspiratory muscle strength, functional capacity, respiratory functions, physical activity, and quality of life in individuals with COPD.

Conditions

Copd

Outcome Measures

Primary Outcomes (9)

• Inspiratory Muscle Strength

  Maximal Inspiratory Pressure (MIP) (cmH2O),

  8 weeks

• Inspiratory Muscle Activation

  surface EMG (TLC from FRC (TLC maneuver)(cmH2O)

  8 weeks

• Respiratory function tests FEV1

  Spirometry, FEV1 (lt)

  8 weeks

• Respiratory function tests FVC

  Spirometry, FVC (lt)

  8 weeks

• Respiratory function tests PEF

  Spirometry, PEF (lt/sn)

  8 weeks

• Respiratory function tests FEV1/FVC

  Spirometry, FEV1/FVC %

  8 weeks

• Respiratory function MVV

  Spirometry, MVV(L/min)

  8 weeks

• Functional capacity

  Six Minute Walking Test (6MVT) (m)

  8 weeks

• Symptoms

  MMRC Dyspnea Scale (Scores range from 0 to 4)

  8 weeks

Secondary Outcomes (6)

• Physical activity,

  8 week

• Quality of life Tests

  8 week

• Core Strength

  8 week

• Core Strength flexion

  8 week

• Core Strength extension

  8 week

Study Arms (2)

İnspiratory muscle training

OTHER

Inspiratory muscle training during 8 weeks

Other: İnspiratory muscle training

Core Stabilization

OTHER

Inspiratory muscle training and core training during 8 weeks

Other: İnspiratory muscle training; Other: Core training

Interventions

İnspiratory muscle training OTHER

exercises to strengthen inspiratory muscles

Also known as: Normal breath exercises and İnspiratory muscle training

Core Stabilization; İnspiratory muscle training

Core training OTHER

exercises to strengthen inspiratory and core muscles

Also known as: Normal breath exercises and İnspiratory muscle training and Core Stabilization

Core Stabilization

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Being over 18 years old
• Having a diagnosis of COPD according to the GOLD criteria and being at stage 3 or lower
• Not being in an acute exacerbation period and having at least one month since the last exacerbation
• Being able to walk independently
• Having sufficient mental capacity to understand the tasks in the study (Mini-Mental Test \>24)
• Being willing to participate in the study

You may not qualify if:

• Being a stage 4 COPD patient according to the GOLD criteria
• Having a diagnosis of lung cancer, pulmonary hypertension, and heart failure
• Being in a COPD exacerbation period
• Scoring below 24 on the Mini-Mental Test
• Having any other disease that affects respiratory functions
• Having undergone pulmonary surgery

Sponsors & Collaborators

• Mustafa Ertuğrul Yaşa: lead

Study Sites (1)

Sağlık Bilimleri Üniversitesi

Ankara, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: assistant professor

Study Record Dates

• First Submitted: July 3, 2024
• First Posted: July 19, 2024
• Study Start: October 1, 2024
• Primary Completion: May 3, 2025
• Study Completion: June 5, 2025
• Last Updated: September 5, 2025

Record last verified: 2025-08

Locations

TU (1)