NCT06575894

Brief Summary

Depression and anxiety during and after pregnancy are common medical complications contributing to a rising maternal mortality rate. Home visiting programs can offer evidence-based interventions to improve mental health outcomes for a vulnerable pregnant population; however, barriers remain to achieving the full potential of these interventions. Our work will explore the impact of context on the implementation of a mental health intervention to provide action-based and impactful data that focuses on the lived experiences of the diverse populations served by home visiting programs in Iowa and Indiana.

Trial Health

75
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,750

participants targeted

Target at P75+ for not_applicable

Timeline
34mo left

Started Apr 2026

Typical duration for not_applicable

Geographic Reach
1 country

2 active sites

Status
enrolling by invitation

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress3%
Apr 2026Feb 2029

First Submitted

Initial submission to the registry

August 22, 2024

Completed
6 days until next milestone

First Posted

Study publicly available on registry

August 28, 2024

Completed
1.6 years until next milestone

Study Start

First participant enrolled

April 1, 2026

Completed
2.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 28, 2029

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

February 28, 2029

Last Updated

April 20, 2026

Status Verified

April 1, 2026

Enrollment Period

2.9 years

First QC Date

August 22, 2024

Last Update Submit

April 15, 2026

Conditions

Keywords

perinatalhome visitingcontextethnography

Outcome Measures

Primary Outcomes (2)

  • Adoption

    Percent of home visitors who deliver Mothers and Babies intervention to program recipients

    From date of recruitment assessed up to 12 months (3 months postpartum)

  • Fidelity

    Percent of home visitors who deliver all 9 sessions of Mothers and Babies to program recipients

    From date of recruitment assessed up to 12 months (3 months postpartum)

Secondary Outcomes (1)

  • Depressive Symptoms

    From date of recruitment assessed up to 12 months (3 months postpartum)

Study Arms (3)

HV Supervisor Refused

NO INTERVENTION

Home visitors outside the trial will receive no implementation support from their supervisors with respect to the Mothers and Babies intervention.

Standard Implementation

ACTIVE COMPARATOR

Control arm home visitors will receive standard Mothers and Babies implementation support from their supervisors.

Behavioral: Standard Implementation

Adapted Facilitation

EXPERIMENTAL

Home visitors in the adapted facilitation group will receive standard Mothers and Babies support plus adapted facilitation delivered by home visiting supervisors trained in adapted implementation facilitation.

Behavioral: Adapted Facilitation

Interventions

Home visiting supervisor trained in adapted facilitation will employ interactive problem-solving focused on supporting the home visitors to implement Mothers and Babies - working with pregnant people, challenges with resources, additional training needs, etc. - based on understanding the individual communities, contexts, and recipients' and home visitors' needs over the course of the project.

Adapted Facilitation

Standard Mothers and Babies training includes ongoing implementation support from the Mothers and Babies training team

Standard Implementation

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Affiliated as staff or volunteer with a home visiting program in Iowa or Indiana at the time of enrollment
  • Aged 18 years or older

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Indiana Department of Health

Indianapolis, Indiana, 46204, United States

Location

Department of Health and Human Services

Des Moines, Iowa, 50319, United States

Location

Related Publications (1)

  • Faro EZ, Jones D, Adeagbo M, Cho H, Swartzendruber G, Tabb KM, Tandon SD, Ryckman K. Can an evidence-based mental health intervention be implemented into preexisting home visiting programs using implementation facilitation? Study protocol for a three variable implementation effectiveness context hybrid trial. Implement Sci. 2024 Nov 11;19(1):76. doi: 10.1186/s13012-024-01402-7.

MeSH Terms

Conditions

Mental Disorders

Study Officials

  • Elissa Z Faro, PhD

    Hackensack Meridian Health

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
HEALTH SERVICES RESEARCH
Intervention Model
PARALLEL
Model Details: pragmatic cluster randomized trial
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 22, 2024

First Posted

August 28, 2024

Study Start

April 1, 2026

Primary Completion (Estimated)

February 28, 2029

Study Completion (Estimated)

February 28, 2029

Last Updated

April 20, 2026

Record last verified: 2026-04

Data Sharing

IPD Sharing
Will share

Coded interview/focus group transcript data will be both preserved and shared through relevant publications or other dissemination (e.g., conference presentations). Interview/focus group/observation transcript data will be deposited with NIMH Data Archive (NDA), located within a broad-use permission group where data will only be accessible to researchers who submit a Data Use Certification (DUC) and who meet the NDA's criteria to request access. The DUC includes terms that prohibit the attempt of reidentification. Survey responses will be both preserved and shared. Aggregate data and codebooks will be shared with relevant publications or by the end of the project period. Aggregate data is a dataset comprised of the consolidation of data relating to multiple survey participants, and therefore cannot be traced back to a specific participant. Respondent identifiers will not be shared. De-identified survey data will also be deposited with NDA.

Shared Documents
SAP, ANALYTIC CODE
Time Frame
As approved by the NDA
Access Criteria
Data will only be accessible to researchers who submit a Data Use Certification (DUC) and who meet the NDA's criteria to request access.

Locations