Therapeutic Effect of Methalazine on 27 Cases of Suppurative Hidradenitis

NCT06568224 | Completed

• 1 other identifier: HouMaihua
• Study Type: observational
• Target: 27
• Locations: 1 country
• Sites: 1

Brief Summary

Background: Hidradenitis suppurativa (HS) is a chronic inflammatory relapsing disease involving the axillae, breast ,groin and anogenital regions. The therapies of the disease are diverse, including medication and surgery. However, responses to treatments are variable and relapse is common, with no single agent being consistently effective. Objective: To evaluate the efficacy and safety of oral mesalazine treatment for hidradenitis suppurativa . Methods: Investigators reported a series of cases of patients who received oral mesalazine(1g qid) for hidradenitis suppurativa in our institution between May 2020 and September 2023. A total of 27 patients, 22 in the mild to moderate group and 5 in the severe group, were included in this study.

Conditions

Hidradenitis Suppurativa

Outcome Measures

Primary Outcomes (1)

• Therapeutic Effect of Methalazine on 27 Cases of Suppurative Hidradenitis

  We registered the number of patients who achieved HiSCR（%）.

  Three and a half years

Interventions

Mesalazine DRUG

oral mesalazine 1g qid

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The symptoms of the patients were papules, nodules, cysts, sinuses, pustules, fistulas and scars in the armpits, groin, buttocks, etc., often accompanied by significant pain and tenderness.

You may qualify if:

• Recurrent painful or suppurative lesions
• Typical clinical manifestations: the distribution of apocrine sweat glands is deep in painful nodules, abscesses, sinuses, scars;

You may not qualify if:

• Severe neurological and psychiatric diseases
• Tumor diseases
• Pregnant women in lactation period

Sponsors & Collaborators

• The First Affiliated Hospital with Nanjing Medical University: lead

Study Sites (1)

Jiangsu Provincial People's Hospital

Nanjing, Nanjing, 210029, China

Location

MeSH Terms

Conditions

Hidradenitis Suppurativa

Interventions

Mesalamine

Condition Hierarchy (Ancestors)

Skin Diseases, Bacterial; Bacterial Infections; Bacterial Infections and Mycoses; Infections; Skin Diseases, Infectious; Suppuration; Skin Diseases; Skin and Connective Tissue Diseases; Hidradenitis; Sweat Gland Diseases

Intervention Hierarchy (Ancestors)

meta-Aminobenzoates; Aminobenzoates; Benzoates; Acids, Carbocyclic; Carboxylic Acids; Organic Chemicals; Aminosalicylic Acids; Salicylates; Hydroxybenzoates; Hydroxy Acids; Benzene Derivatives; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic; Hydrocarbons; Phenols

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Chief physician

Study Record Dates

• First Submitted: May 27, 2024
• First Posted: August 23, 2024
• Study Start: May 1, 2020
• Primary Completion: September 1, 2023
• Study Completion: September 1, 2023
• Last Updated: September 3, 2024

Record last verified: 2024-08

Locations

CN (1)