Hidradenitis - an Analysis of Genetic Traits and Linkages in Families

NCT05710393 | Terminated

• 1 other identifier: IRB18-1861
• Study Type: observational
• Target: 97
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to find a genetic link or family trait connecting persons with Hidradenitis Suppurativa (HS) to each other. As a result, discover the cause and perhaps treatment for Hidradenitis Suppurativa (HS).

Conditions

Hidradenitis Suppurativa

Keywords

Hidradenitis Suppurativa; HS; Acne inversa; Abscess; Boils

Outcome Measures

Primary Outcomes (1)

• Hidradenitis Suppurativa Genetic linkage

  Determine the genetic linkage of Hidradenitis Suppurativa (HS). Measurements are based on Gene panel assays of DNA specimen (blood or saliva) to find rare variant(s) linked to HS. Specimen samples include those provided by affected participants, and when possible they're biological family. A Gene panel diagnostic determines the number of variants (or mutation) in multiple genes, potentially identifying a genetic linkage of mendelian inheritance.

  1-Day Study Participation

Secondary Outcomes (3)

• Demographics of Participant Population

  1-Day Study Participation

• Pattern of Affected Family

  1-Day Study Participation

• Number of Variants Shared

  1-Day Study Participation

Study Arms (2)

Affected

(Affected) persons with a medical history of symptoms related to Hidradenitis Suppurativa.

Unaffected-control

(Unaffected) family of participants, having no history of symptoms related to Hidradenitis Suppurativa.

Eligibility Criteria

• Age: 7 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Participants with a history of Hidradenitis Suppurativa, and their biological family members.

You may qualify if:

• Participants (affected) with Hidradenitis Suppurativa and related symptoms
• Family (unaffected) of participants with Hidradenitis Suppurativa

You may not qualify if:

• Children under 7-years of age

Sponsors & Collaborators

• University of Chicago: lead

Study Sites (1)

University of Chicago Medicine

Chicago, Illinois, 60637, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

Blood (adults, approx. 8-9 mL), (pediatric, 2-4 mL); or Saliva (1.5 - 2.0 mL) specimen for DNA (Gene panel) analysis.

MeSH Terms

Conditions

Hidradenitis Suppurativa; Abscess; Furunculosis

Condition Hierarchy (Ancestors)

Skin Diseases, Bacterial; Bacterial Infections; Bacterial Infections and Mycoses; Infections; Skin Diseases, Infectious; Suppuration; Skin Diseases; Skin and Connective Tissue Diseases; Hidradenitis; Sweat Gland Diseases; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Staphylococcal Skin Infections; Staphylococcal Infections; Gram-Positive Bacterial Infections; Fish Diseases; Animal Diseases

Study Officials

• Peter Nagele, MD, MSc

  University of Chicago Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: FAMILY BASED
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 25, 2023
• First Posted: February 2, 2023
• Study Start: September 17, 2019
• Primary Completion: February 27, 2026
• Study Completion: February 27, 2026
• Last Updated: March 4, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)