Protocol for Evaluating Physiological and Psychological Adaptation Mechanisms in Tibetan Plateau Environments

NCT06557928 | Enrolling By Invitation

• 1 other identifier: 2022-I2M-1-003
• Study Type: observational
• Target: 17
• Locations: 1 country
• Sites: 1

Brief Summary

This study is a single-center prospective observational study. It plans to use a series of physiological and medical instruments and international common physiological and psychological questionnaires. To dynamically detect the changes of physiological and psychological adaptability of doctors in Peking Union Medical College Hospital before leaving Beijing, 1-7 days after arriving at the plateau in Tibet during the acute phase of plateau hypoxic stress, 2 weeks, 3 months, 6 months, 12 months after staying in Tibet during the chronic phase of plateau hypoxic stress, and after returning to Beijing.

Conditions

High Altitude

Keywords

high altitude; adaptation; acclimatization

Outcome Measures

Primary Outcomes (1)

• help understand the physiological mechanisms and psychological changes of hypoxic adaptation

  This study is expected to increase our understanding of the physiological mechanisms and psychological changes of hypoxic adaptation mainly through analysis of multi-omics.

  2024-5-27~2026-12-1

Study Arms (2)

Doctors to Tibet from Peking Union Medical College Hospital in 2024

Other: measurement

Doctors to Tibet from Peking Union Medical College Hospital in 2025

Other: measurement

Interventions

measurement OTHER

Measurement of multiple physiological indicators and psychological status and multi-omics study

Doctors to Tibet from Peking Union Medical College Hospital in 2024; Doctors to Tibet from Peking Union Medical College Hospital in 2025

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Doctors in Tibet from Peking Union Medical College Hospital

You may qualify if:

• Healthy individuals aged 20-65 years
• They can sign a written informed consent and is willing to cooperate
• They have the qualification to aid Tibet and meet the basic requirements of physical examination for aid to Tibet

You may not qualify if:

• Age less than 20 years or more than 65 years
• Unable to sign a written informed consent or unwilling to cooperate
• They do not have the qualification for supporting Tibet or do not meet the basic requirements of medical examination for supporting Tibet

Sponsors & Collaborators

• Peking Union Medical College Hospital: lead

Study Sites (1)

Peking Union Medical College Hospital

Beijing, China

Location

MeSH Terms

Conditions

Altitude Sickness

Interventions

Weights and Measures

Condition Hierarchy (Ancestors)

Respiration Disorders; Respiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Investigative Techniques

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Gastroenterology

Study Record Dates

• First Submitted: August 14, 2024
• First Posted: August 16, 2024
• Study Start: May 17, 2024
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 1, 2027
• Last Updated: August 16, 2024

Record last verified: 2024-08

Locations

CN (1)