Autonomic Nervous System Dysregulation in People With Chronic Neck Pain

NCT06554704 | Completed

• 1 other identifier: NYCU113077AE
• Study Type: observational
• Target: 56
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to investigate heart rate variability in different positions and in response to isometric hand-grip test in people with non-specific chronic neck pain as compared with healthy controls. The main questions it aims to answer are:

• Do the heart rate variability indices differ between people with non-specific chronic neck pain and healthy controls in supine sitting and standing positions?
• Do the heart rate variability indices differ between people with non-specific chronic neck pain and healthy controls when challenged by the isometric hand-grip test?

Conditions

Chronic Neck Pain; Autonomic Nervous System

Keywords

Heart rate variability; Isometric hand-grip test; Posture

Outcome Measures

Primary Outcomes (1)

• Heart rate variability

  Time domain and frequency domain indices

  Five-minute

Study Arms (2)

Chronic neck pain

Individuals with non-specific chronic neck pain

Behavioral: Isometric hand grip test

Healthy control

Individuals without non-specific chronic neck pain

Behavioral: Isometric hand grip test

Interventions

Isometric hand grip test BEHAVIORAL

The five-minute heart rate variability and respiration rate will be measured for each condition including resting in supine, sitting and standing position, as well as the isometric hand grip test in supine, sitting and standing position.

Chronic neck pain; Healthy control

Eligibility Criteria

• Age: 20 Years - 59 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of healthy participants with or without chronic neck pain, recruited in Taipei.

You may qualify if:

• Chronic pain (persistent or recurrent pain \>90 days)
• Non-specific chronic neck pain and non-irradiated to the upper limbs (Superior nuchal line \~ scapular spine \~ acromion)
• Age- and gender- matched (age: 20\~59 y/o)
• BMI between 18.5\~24.9 (Normal weight)
• Work at least 75% of full-time work

You may not qualify if:

• Neurological diseases
• Orthopedic disorders
• Other disorders or regular use of medications known to affect physical activity, autonomic nervous system or pain perception

Sponsors & Collaborators

• National Yang Ming Chiao Tung University: lead

Study Sites (1)

National Yang-Ming University, Taiwan, R.O.C.

Taipei, 112, Taiwan

Location

Study Officials

• Ray-Yau Wang

  National Yang Ming Chiao Tung University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 12, 2024
• First Posted: August 15, 2024
• Study Start: September 29, 2024
• Primary Completion: October 26, 2025
• Study Completion: October 27, 2025
• Last Updated: December 10, 2025

Record last verified: 2024-07

Locations

TW (1)