Identification of Serum Level of Glutathione Peroxidase 4

NCT06554392 | Not Yet Recruiting

• 1 other identifier: Glutathione Peroxidase 4
• Study Type: observational
• Target: 85
• Locations: 0 countries
• Sites: N/A

Brief Summary

• Analysis of the level of glutathione peroxidase 4 (GPX4) in ankylosing spondylitis and axial psoriatic arthritis patients.
• The association of glutathione peroxidase 4 (GPX4) with disease activity and severity in ankylosing spondylitis and axial psoriatic arthritis patients.

Conditions

Spondyloarthropathy

Outcome Measures

Primary Outcomes (1)

• Analysis of the serum level of glutathione peroxidase 4 (GPX4) in ankylosing spondylitis and axial psoriatic arthritis patients.

  Analysis of the serum level of glutathione peroxidase 4 (GPX4) in ankylosing spondylitis and axial psoriatic arthritis patients to detect ferroptosis process in those patients.

  baseline

Secondary Outcomes (1)

• The association of glutathione peroxidase 4 (GPX4) with disease activity and severity in ankylosing spondylitis and axial psoriatic arthritis patients.

  baseline

Study Arms (3)

Ankylosing Spondylitis patients

Identification of Glutathione Peroxidase 4 in blood.

Diagnostic Test: Blood sample

Axial Psoriatic Arthritis Patients

Identification of Glutathione Peroxidase 4 in blood.

Diagnostic Test: Blood sample

healthy controls

Identification of Glutathione Peroxidase 4 in blood.

Diagnostic Test: Blood sample

Interventions

Blood sample DIAGNOSTIC_TEST

Blood sample from each subject to detect Glutathione Peroxidase 4.

Ankylosing Spondylitis patients; Axial Psoriatic Arthritis Patients; healthy controls

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients will be selected from AS and axial psoriatic arthritis patients presented sequentially at the outpatient clinic and inpatient unit of the Department of Rheumatology, Rehabilitation and Physical Medicine. Faculty of Medicine .Assiut University.in addition to age and sex matched controls.

You may qualify if:

• Patients diagnosed as ankylosing spondylitis according to ASAS criteria . \[13\]
• Patients diagnosed as psoriatic arthritis according to CASPAR criteria. \[14\]
• Age (\>18).

You may not qualify if:

• Patient with other autoimmune Rheumatic diseases.
• patients with any of the following conditions: I) severe liver and kidney dysfunction; II) hematopoietic diseases; III) infectious diseases; IV) tumors; or V) other wasting diseases. \[15\]
• patients received certain drugs (for example, sulfasalazine, artemisinin, statins), and experimental reagents (such as erastin) .\[16\]

Sponsors & Collaborators

• Assiut University: lead

Related Publications (5)

• Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison B 3rd, Stockwell BR. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012 May 25;149(5):1060-72. doi: 10.1016/j.cell.2012.03.042.

  PMID: 22632970 BACKGROUND

• Chen R, Zhu S, Zeng L, Wang Q, Sheng Y, Zhou B, Tang D, Kang R. AGER-Mediated Lipid Peroxidation Drives Caspase-11 Inflammasome Activation in Sepsis. Front Immunol. 2019 Aug 8;10:1904. doi: 10.3389/fimmu.2019.01904. eCollection 2019.

  PMID: 31440260 BACKGROUND

• Yuan S, Wei C, Liu G, Zhang L, Li J, Li L, Cai S, Fang L. Sorafenib attenuates liver fibrosis by triggering hepatic stellate cell ferroptosis via HIF-1alpha/SLC7A11 pathway. Cell Prolif. 2022 Jan;55(1):e13158. doi: 10.1111/cpr.13158. Epub 2021 Nov 22.

  PMID: 34811833 BACKGROUND

• Gao M, Yi J, Zhu J, Minikes AM, Monian P, Thompson CB, Jiang X. Role of Mitochondria in Ferroptosis. Mol Cell. 2019 Jan 17;73(2):354-363.e3. doi: 10.1016/j.molcel.2018.10.042. Epub 2018 Dec 20.

  PMID: 30581146 BACKGROUND

• Chen X, Kang R, Kroemer G, Tang D. Ferroptosis in infection, inflammation, and immunity. J Exp Med. 2021 Jun 7;218(6):e20210518. doi: 10.1084/jem.20210518. Epub 2021 May 12.

  PMID: 33978684 BACKGROUND

MeSH Terms

Conditions

Spondylarthropathies

Interventions

Blood Specimen Collection

Condition Hierarchy (Ancestors)

Spondylarthritis; Spondylitis; Spinal Diseases; Bone Diseases; Musculoskeletal Diseases; Arthritis; Joint Diseases

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Study Officials

• Marwa Abdelaziz, Prof.

  Rheumatology,Rehabilition,Physical therapy Department ,Assiut university

  STUDY DIRECTOR

• Marwa Galal, Ass. Prof.

  Rheumatology,Rehabilition,Physical therapy Department ,Assiut university

  STUDY DIRECTOR

• Nesreen Ibrahim, Dr

  Rheumatology,Rehabilition,Physical therapy Department ,Assiut university

  STUDY DIRECTOR

Central Study Contacts

Gehad Fahem, Rd

CONTACT

+201116770486; gehad.16297444@med.aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Target Duration: 3 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: resident doctor

Study Record Dates

• First Submitted: August 11, 2024
• First Posted: August 15, 2024
• Study Start: September 1, 2024
• Primary Completion (Estimated): September 1, 2026
• Study Completion (Estimated): July 1, 2027
• Last Updated: August 15, 2024

Record last verified: 2024-08