Cardiotoxicity of Carbon Monoxide in Patients Treated With Hyperbaric Oxygen Therapy

NCT06549621 | Recruiting

• 1 other identifier: COCARDIOTOX (29BRC22.0049)
• Study Type: observational
• Target: 66
• Locations: 1 country
• Sites: 1

Brief Summary

Carbon monoxide poisoning is a frequent domestic accident and the leading cause of death from unintentionnal poisoning. Its toxicity is based on the CO binding to hemoglobin and myoglobin, inhibition of mitochondrial cytochrome oxidase, resulting in tissue hypoxia and reduced adenosine triphosphate synthesis and ischemia-reperfusion injury. This study aims to investigate the early and late cardiologic effects of CO in patients treated with hyperbaric oxygen (HBOT) for CO poisoning

Conditions

Carbon Monoxide Poisoning

Keywords

cardiac injury; cardiac toxicity

Outcome Measures

Primary Outcomes (1)

• early and late cardiac injury due to CO poisoning description

  clinical manifestation, troponin elevation and/or ECG abnormality during acute CO poisoning description; then late cardiac manifestation and abnormality declared by patients who have had early cardiac abnormality (troponin elevation and/or ECG abnormalities)

  enrollment (inclusion)

Secondary Outcomes (5)

• relationship between the source of CO poisoning and cardiac injury

  enrollment (inclusion)

• relationship between context of poisoning (domestic, professionnal or intentional poisoning) and cardiac injury

  enrollment (inclusion)

• relationship between other possibly associated poisoning and cardiac injury

  enrollment (inclusion)

• relationship between severity of neurological symptoms and cardiac injury

  enrollment (inclusion)

• relationship between cardiovascular risk factors or preexisting cardio vascular abnormality and cardiac injury

  enrollment (inclusion)

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients treated for CO poisoning with HBOT following European and French recommendations in our department from 2015/01/01 to 2021/12/31

You may qualify if:

• Patients treated for CO poisoning with HBOT in the hyperbaric and underwater medicine department of the Brest University hospital from 2015/01/01 to 2021/12/31

You may not qualify if:

• refusal

Sponsors & Collaborators

• University Hospital, Brest: lead

Study Sites (1)

CHRU de Brest

Brest, 29909, France

RECRUITING

MeSH Terms

Conditions

Carbon Monoxide Poisoning; Cardiotoxicity

Condition Hierarchy (Ancestors)

Gas Poisoning; Poisoning; Chemically-Induced Disorders; Heart Diseases; Cardiovascular Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Drug-Related Side Effects and Adverse Reactions; Radiation Injuries; Wounds and Injuries

Central Study Contacts

anne Henckes

CONTACT

02 98 34 70 98; anne.henckes@chu-brest.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 8, 2024
• First Posted: August 12, 2024
• Study Start: July 25, 2022
• Primary Completion: October 25, 2022
• Study Completion: October 25, 2024
• Last Updated: August 12, 2024

Record last verified: 2024-08

Locations

FR (1)