Comparison of the Effectiveness of Treatments in Carbon Monoxide Intoxications

NCT06198595 | Completed

• 1 other identifier: E2-23-5424
• Study Type: observational
• Target: 66
• Locations: 1 country
• Sites: 1

Brief Summary

Carbon monoxide (CO) poisoning is a condition that occurs as a result of inhaling carbon monoxide gas and can potentially lead to serious health issues. The treatment of CO poisoning requires urgent medical intervention. Methods used in the treatment of CO poisoning include normobaric oxygen (oxygen at normal pressure), high-flow oxygen, non-invasive continuous positive airway pressure (CPAP), and hyperbaric oxygen therapy. Studies on these methods are available in the literature.

Conditions

Carbon Monoxide Poisoning

Outcome Measures

Primary Outcomes (2)

• Carboxyhemoglobin

  Blood carboxyhemoglobin saturation is typically expressed as a percentage. For example, the statement "blood carboxyhemoglobin saturation is 5%" indicates that 5% of hemoglobin has been converted to carboxyhemoglobin. This ratio affects the oxygen-carrying capacity of the blood and serves as an indicator of carbon monoxide poisoning. After treatment, a decrease in this ratio signifies the elimination of carbon monoxide from the body and the restoration of normal oxygen-carrying function.

  6 hours later

• lactate

  Blood lactate levels are typically measured in millimoles per liter (mmol/L)

  6 hours later

Study Arms (3)

Normobaric oxygen therapy group

"Patients Receiving Oxygen from Hospital Circuits at Normal Atmospheric Pressure"

Noninvasive mechanical ventilation group

"Patients Receiving High PEEP Oxygenation Without Advanced Airway via Mechanical Ventilation"

EzPAP Positive Airway Pressure System

"Patients Receiving Positive Airway Pressure Support for Lung Expansion Without Advanced Airway via the EzPAP Device."

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients who present to the emergency department with or are brought in due to CO intoxication will be included in the study.

You may qualify if:

• Between the ages of 18 and 65,
• Without any underlying health conditions,
• Diagnosed with carbon monoxide poisoning,
• Capable of providing consent either personally or through a legal representative.

You may not qualify if:

• Under the age of 18,
• Over the age of 65,
• With underlying health conditions,
• Without a diagnosis of carbon monoxide poisoning,
• Patients who do not wish to share their data.

Sponsors & Collaborators

• Ankara City Hospital Bilkent: lead

Study Sites (1)

Ankara Bilkent Şehir Hastanesi

Ankara, Çankaya, 06170, Turkey (Türkiye)

Location

Related Publications (6)

• Akkan S, Uyanik O. Comparing high-flow nasal oxygen therapy and normobaric oxygen therapy on the treatment of carbon monoxide poisoning. Med Klin Intensivmed Notfmed. 2024 Apr;119(3):214-219. doi: 10.1007/s00063-023-01044-5. Epub 2023 Aug 2.

  PMID: 37530814 BACKGROUND

• Kim YM, Shin HJ, Choi DW, Kim JM, Lee SW, Jeong SH, Kim H. Comparison of high-flow nasal cannula oxygen therapy and conventional reserve-bag oxygen therapy in carbon monoxide intoxication: A pilot study. Am J Emerg Med. 2020 Aug;38(8):1621-1626. doi: 10.1016/j.ajem.2019.158451. Epub 2019 Nov 6.

  PMID: 31706658 BACKGROUND

• Ozturan IU, Yaka E, Suner S, Ozbek AE, Alyesil C, Dogan NO, Yilmaz S, Pekdemir M. Determination of carboxyhemoglobin half-life in patients with carbon monoxide toxicity treated with high flow nasal cannula oxygen therapy. Clin Toxicol (Phila). 2019 Jul;57(7):617-623. doi: 10.1080/15563650.2018.1540046. Epub 2019 Jan 28.

  PMID: 30689450 BACKGROUND

• Turgut K, Yavuz E. CPAP versus HFNC use in carbon monoxide poisoning. Am J Emerg Med. 2021 Aug;46:727. doi: 10.1016/j.ajem.2020.09.085. Epub 2020 Oct 2. No abstract available.

  PMID: 33036847 BACKGROUND

• Roth D, Mayer J, Schreiber W, Herkner H, Laggner AN. Acute carbon monoxide poisoning treatment by non-invasive CPAP-ventilation, and by reservoir face mask: Two simultaneous cases. Am J Emerg Med. 2018 Sep;36(9):1718.e5-1718.e6. doi: 10.1016/j.ajem.2018.05.066. Epub 2018 May 29.

  PMID: 29866417 BACKGROUND

• Caglar B, Serin S, Yilmaz G, Torun A, Parlak I. The Impact of Treatment with Continuous Positive Airway Pressure on Acute Carbon Monoxide Poisoning. Prehosp Disaster Med. 2019 Dec;34(6):588-591. doi: 10.1017/S1049023X19005028. Epub 2019 Oct 22.

  PMID: 31637993 BACKGROUND

MeSH Terms

Conditions

Carbon Monoxide Poisoning

Condition Hierarchy (Ancestors)

Gas Poisoning; Poisoning; Chemically-Induced Disorders

Study Officials

• SAFA DÖNMEZ, MD

  ANKARA BİLKENT CİTY HOSPİTAL

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 11, 2023
• First Posted: January 10, 2024
• Study Start: November 1, 2023
• Primary Completion: June 30, 2024
• Study Completion: July 30, 2024
• Last Updated: January 31, 2025

Record last verified: 2025-01

Locations

TU (1)