Acute Kidney Injury After Cardiac Arrest

NCT06544538 | Completed DMC

• 1 other identifier: 2023/250
• Study Type: observational
• Target: 82
• Locations: 1 country
• Sites: 1

Brief Summary

The development of AKI (Acute Kidney Injury) after cardiac arrest is a common factor associated with mortality. In this study, we aimed to evaluate the factors that increase the risk of developing AKI after cardiac arrest. For the study, patients were evaluated for the incidence of acute kidney injury (AKI), factors that increase the risk of AKI, and the impact of AKI on mortality. In this process, demographic data, comorbidities, hemodynamic data, laboratory data, clinical symptoms and findings recorded in the electronic decision support system were recorded and analyzed.

Conditions

Acute Kidney Injury

Keywords

cardiac arrest; Acute kidney injury; Mortality

Outcome Measures

Primary Outcomes (1)

• Acute Kidney Injury (AKI)

  Creatinine values in the first 48 hours of intensive care unit admission after cardiac arrest

  Within 48 hours after intensive care unit admission

Secondary Outcomes (2)

• AKI incidence

  Within 48 hours after intensive care unit admission

• Mortality

  Clinical and laboratory data within 48 hours after intensive care unit admission will be used

Study Arms (2)

AKI Group

AKI 1-3 in the first 48 hours after cardiac arrest according to KDIGO 2012 criteria

Non-AKI Group

Those who did not develop AKI in the first 48 hours after cardiac arrest according to KDIGO 2012 criteria

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients admitted to the Anesthesiology and Reanimation intensive care unit of Bakırköy Dr. Sadi Konuk Training and Research Hospital after cardiac arrest

You may qualify if:

• adult patients with spontaneous circulation after cardiac arrest and admitted to the intensive care unit

You may not qualify if:

• Deaths in the first 48 hours
• Missing data
• End stage CKD or first day hemadsorption
• CPR time \<3 min
• Unwitnessed cardiac arrest
• Terminal malignancy
• years old
• Having a pace marker
• Massive bleeding
• ECMO application
• First day diyabetes insipitus

Sponsors & Collaborators

• Bakirkoy Dr. Sadi Konuk Research and Training Hospital: lead

Study Sites (1)

Bakırköy Dr. Sadi Konuk Training and Research Hospital

Istanbul, 34140, Turkey (Türkiye)

Location

Related Publications (5)

• Nolan JP, Sandroni C, Bottiger BW, Cariou A, Cronberg T, Friberg H, Genbrugge C, Haywood K, Lilja G, Moulaert VRM, Nikolaou N, Olasveengen TM, Skrifvars MB, Taccone F, Soar J. European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2021: post-resuscitation care. Intensive Care Med. 2021 Apr;47(4):369-421. doi: 10.1007/s00134-021-06368-4. Epub 2021 Mar 25.

  PMID: 33765189 BACKGROUND

• Kalogeris T, Baines CP, Krenz M, Korthuis RJ. Ischemia/Reperfusion. Compr Physiol. 2016 Dec 6;7(1):113-170. doi: 10.1002/cphy.c160006.

  PMID: 28135002 BACKGROUND

• Lemiale V, Dumas F, Mongardon N, Giovanetti O, Charpentier J, Chiche JD, Carli P, Mira JP, Nolan J, Cariou A. Intensive care unit mortality after cardiac arrest: the relative contribution of shock and brain injury in a large cohort. Intensive Care Med. 2013 Nov;39(11):1972-80. doi: 10.1007/s00134-013-3043-4. Epub 2013 Aug 14.

  PMID: 23942856 BACKGROUND

• Adler C, Reuter H, Seck C, Hellmich M, Zobel C. Fluid therapy and acute kidney injury in cardiogenic shock after cardiac arrest. Resuscitation. 2013 Feb;84(2):194-9. doi: 10.1016/j.resuscitation.2012.06.013. Epub 2012 Jun 30.

  PMID: 22750662 BACKGROUND

• Patyna S, Riekert K, Buettner S, Wagner A, Volk J, Weiler H, Erath-Honold JW, Geiger H, Fichtlscherer S, Honold J. Acute kidney injury after in-hospital cardiac arrest in a predominant internal medicine and cardiology patient population: incidence, risk factors, and impact on survival. Ren Fail. 2021 Dec;43(1):1163-1169. doi: 10.1080/0886022X.2021.1956538.

  PMID: 34315321 BACKGROUND

MeSH Terms

Conditions

Acute Kidney Injury; Heart Arrest

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Heart Diseases; Cardiovascular Diseases

Study Officials

• MURAT ASLAN, Dr

  Istanbul Bakırköy Dr Sadi Konuk Training and Research Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 27, 2024
• First Posted: August 9, 2024
• Study Start: January 1, 2013
• Primary Completion: December 31, 2022
• Study Completion: December 31, 2022
• Last Updated: August 9, 2024

Record last verified: 2024-08

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF
• Time Frame: to be determined later
• Access Criteria: to be determined later

Locations

TU (1)