Dural Arteriovenous Fistulas Research at China INI

NCT06543472 | Recruiting

• 1 other identifier: XW0630
• Study Type: observational
• Target: 1,180
• Locations: 1 country
• Sites: 1

Brief Summary

Dural arteriovenous fistula (DAVF) refers to abnormal connections between meningeal arteries and dural venous sinuses and/or subarachnoid veins. DAVF accounts for approximately 10% to 15% of intracranial vascular malformations. With advancements in imaging technology, increased awareness among physicians, and an aging population, the incidence of DAVF appears to be on the rise. Some literature even suggests it may surpass the occurrence of arteriovenous malformations. Several large-scale retrospective studies have been conducted internationally, involving over 1,000 cases, but some of their findings differ from what is commonly understood. Currently, there is a lack of large-sample single-center studies on DAVF, highlighting the urgent need for such research.

Conditions

Fistula

Outcome Measures

Primary Outcomes (1)

• Long term prognosis

  Safety endpoints include perioperative and postoperative complications, as well as the clinical status of the patients. This is evaluated using the preoperative modified Rankin Scale (mRS), mRS at discharge, and mRS at 6 to 12 months, along with the most recent clinical (inpatient/outpatient) or telephone follow-up. Efficacy endpoints include the immediate DAVF occlusion status after the last treatment, and the results from imaging follow-ups (DSA/MRA/CTA) at 6 to 12 months and the latest follow-up.

  assessed at 3, 6, 12 and 24 months after procedure

Secondary Outcomes (1)

• Long-term cure rate

  assessed at 3, 6, 12 and 24 months after procedure

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All are from Chinese individuals.

You may qualify if:

• Adult patients with DAVFs who were admitted to Xuanwu Hospital.

You may not qualify if:

• Non-DAVF lesions confirmed by DSA.

Sponsors & Collaborators

• Xuanwu Hospital, Beijing: lead

Study Sites (1)

Xuanwu Hospital, Capital Medical University

Beijing, China

RECRUITING

Related Publications (1)

• Su X, Li X, Song Z, Chen Y, Huang M, Liu H, Pang H, Zhang C, Sun L, Ye M, Hong T, Ma Y, Zhang H, Zhang P. Tentorial Dural Arteriovenous Fistulas: A Retrospective Cohort Study. Oper Neurosurg. 2025 Nov 1;29(5):678-685. doi: 10.1227/ons.0000000000001524. Epub 2025 Mar 5.

  PMID: 40042314 DERIVED

MeSH Terms

Conditions

Fistula

Condition Hierarchy (Ancestors)

Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Study Officials

• Hongqi Zhang, MD

  Xuanwu Hospital Department of Neurosurgery

  STUDY CHAIR

• Xin Su, MD

  Xuanwu Hospital Department of Neurosurgery

  PRINCIPAL INVESTIGATOR

• Zihao Song, MD

  Xuanwu Hospital Department of Neurosurgery

  PRINCIPAL INVESTIGATOR

• Huiwei Liu, MD

  Xuanwu Hospital Department of Neurosurgery

  PRINCIPAL INVESTIGATOR

• Peng Zhang, MD

  Xuanwu Hospital Department of Neurosurgery

  STUDY DIRECTOR

• Yongjie Ma, MD

  Xuanwu Hospital Department of Neurosurgery

  STUDY DIRECTOR

Central Study Contacts

Peng Zhang, MD

CONTACT

010-83198899; zhangpengwr@126.com

Yongjie Ma, MD

CONTACT

01083198899; mayongjiedoctor@sina.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 4, 2024
• First Posted: August 9, 2024
• Study Start: January 1, 2001
• Primary Completion: October 1, 2024
• Study Completion: December 1, 2024
• Last Updated: August 19, 2024

Record last verified: 2024-07

Locations

CN (1)