Interstitial Lung Disease is a Risk Factor for Cardiovascular Disease

NCT06539962 | Completed

• 1 other identifier: WGEK72024
• Study Type: observational
• Target: 134
• Locations: 1 country
• Sites: 1

Brief Summary

A group of Interstitial pulmonary fibrosis will be recruited from Assiut university hospital outpatient clinic. Evaluation will be done regarding cardiovascular comorbidities (Cardiovascular comorbidities will be evaluated with thorough assessment including; history, ECG, Lipid profile and echocardiography). Lipid profile, CRP and KL-6 level will be assessed for recruited personnel. Regression analysis will be used to identify risk factors for cardiovascular comorbidities among IPF patients.

Conditions

Interstitial Lung Disease; Cardiovascular Morbidity

Outcome Measures

Primary Outcomes (1)

• percentage of patients with IPF who develop cardiovascular comorbidities

  Prevalence, clinical pattern of cardiovascular comorbidities among Interstitial pulmonary fibrosis cases

  6 months

Secondary Outcomes (1)

• accuracy of Krebs von den Lungen-6 (KL-6) to predict cardiovascular comorbidities among Interstitial pulmonary fibrosis cases

  6 months

Interventions

Krebs von den Lungen-6 (KL-6) DIAGNOSTIC_TEST

Krebs von den Lungen-6 (KL-6) will be evaluated for ability to predict cardiovascular comorbidities among IPF patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Demographic characteristics of patients diagnosed with interstitial pulmonary fibrosis and recruited from Assiut university hospital outpatient clinic will be recorded, including sex, age, smoking status, underlying comorbidities, addiction status. Chest symptoms evaluation: Cough, expectoration, hemoptysis, dyspnea, wheeze and chest pain. Comorbidity evaluation; including DM, hypertension, hepatic diseases, renal diseases. Cardiovascular comorbidities thorough assessment including; ECG, Lipid profile and echocardiography. chest radiograph and computed tomography (CT) chest findings will be assessed. Laboratory investigations: Lipid profile, CRP and KL-6 level according to the manufacturer's instructions

You may qualify if:

• Patients diagnosed as Interstitial pulmonary fibrosis

You may not qualify if:

• Patients refusing to participate in the study

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Faculty of Medicine, Assiut University

Asyut, 711111, Egypt

Location

Related Publications (3)

• Agrawal A, Verma I, Shah V, Agarwal A, Sikachi RR. Cardiac manifestations of idiopathic pulmonary fibrosis. Intractable Rare Dis Res. 2016 May;5(2):70-5. doi: 10.5582/irdr.2016.01023.

  PMID: 27195188 BACKGROUND

• Nathan SD, Basavaraj A, Reichner C, Shlobin OA, Ahmad S, Kiernan J, Burton N, Barnett SD. Prevalence and impact of coronary artery disease in idiopathic pulmonary fibrosis. Respir Med. 2010 Jul;104(7):1035-41. doi: 10.1016/j.rmed.2010.02.008. Epub 2010 Mar 2.

  PMID: 20199856 BACKGROUND

• Stainer A, Faverio P, Busnelli S, Catalano M, Della Zoppa M, Marruchella A, Pesci A, Luppi F. Molecular Biomarkers in Idiopathic Pulmonary Fibrosis: State of the Art and Future Directions. Int J Mol Sci. 2021 Jun 10;22(12):6255. doi: 10.3390/ijms22126255.

  PMID: 34200784 BACKGROUND

MeSH Terms

Conditions

Lung Diseases, Interstitial

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases

Study Officials

• Waleed MD Gamal Elddin Khaleel, Ass. Prof.

  Assiut University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor of Chest Diseases

Study Record Dates

• First Submitted: August 2, 2024
• First Posted: August 6, 2024
• Study Start: September 1, 2023
• Primary Completion: September 1, 2024
• Study Completion: October 1, 2024
• Last Updated: August 28, 2025

Record last verified: 2025-08

Locations

EG (1)