Risk Factors and Prognostic Parameters of Interstitial Lung Disease in Children

NCT06125288 | Unknown

• 1 other identifier: ILD in children
• Study Type: observational
• Target: 25
• Locations: 0 countries
• Sites: N/A

Brief Summary

Study the severity and outcome of children with interstitial lung disease

Conditions

Interstitial Lung Disease

Outcome Measures

Primary Outcomes (1)

• number of pediatric patient suffering from complication of interstitial lung disease at assiut university hospital.

  number of patiants present to assiut university with clinical complication (tachycardia -tachapnnea -dysnea - cyanosis ) and lab complication by complete blood count and radiological complication by ( chest x ray - chest msct -echocardiography).

  baseline

Interventions

lab investigation and radiation OTHER

1. . Full history taking including * Environmental factors such as long term exposure to environmental hazards as bacteria, fungi, chemicals, tobacco smoke and air pollution. * Host factors Family history (you have a higher risk of ILD if a close relative has ILD). History of recurrent chest infection. History of exposure to medication such as radiation and chemotherapy. History of Multisystem autoimmune diseases 2. Full examination general and systemic especially chest examination 3. investigation * pulse oximetry. * lab investigation include complete blood count parameters . * radiological investigation including ( echocardiography - MSCT chest - chest -x ray

Eligibility Criteria

• Age: 1 Month - 18 Years
• Sex: all
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

All children with suspected ILD that present to Assiut University Hospital Units

You may qualify if:

• Suspected cases with:
• tachypnea , Hypoxemia less than 90% in room air , rales and wheezes in absence of chest infection , retraction or deformed chest wall .
• pulmonary hypertension by ECG or echocardiography.
• x-ray and CT chest infiltrates.
• Duration of illness more than 1 month.
• Specific cases with:
• symptoms and signs of suspected cases.
• Lung biopsy.

You may not qualify if:

• congenital heart disease.
• bronchopulmonary dysplasia.
• Telangiectasia.
• Duration of illness less than 1 month

Sponsors & Collaborators

• Assiut University: lead

Related Publications (3)

• Fan LL, Kozinetz CA. Factors influencing survival in children with chronic interstitial lung disease. Am J Respir Crit Care Med. 1997 Sep;156(3 Pt 1):939-42. doi: 10.1164/ajrccm.156.3.9703051.

  PMID: 9310017 BACKGROUND

• Clement A, Henrion-Caude A, Fauroux B. The pathogenesis of interstitial lung diseases in children. Paediatr Respir Rev. 2004 Jun;5(2):94-7. doi: 10.1016/j.prrv.2004.01.002.

  PMID: 15135117 BACKGROUND

• Bush A, Cunningham S, de Blic J, Barbato A, Clement A, Epaud R, Hengst M, Kiper N, Nicholson AG, Wetzke M, Snijders D, Schwerk N, Griese M; chILD-EU Collaboration. European protocols for the diagnosis and initial treatment of interstitial lung disease in children. Thorax. 2015 Nov;70(11):1078-84. doi: 10.1136/thoraxjnl-2015-207349. Epub 2015 Jul 1.

  PMID: 26135832 BACKGROUND

MeSH Terms

Conditions

Lung Diseases, Interstitial

Interventions

Radiation

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Physical Phenomena

Study Officials

• Maher Mokhtar Ahmed, Professor

  asiut university hospital

  STUDY DIRECTOR

Central Study Contacts

REHAM KAMAL HAMDI

CONTACT

01065329519; mother2524019@gmail.com

. Yasser Gamal Abd El-Rahman, lecturer

CONTACT

01006238575; Maher.Mokhtar.m.@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assistant lecturer

Study Record Dates

• First Submitted: November 6, 2023
• First Posted: November 9, 2023
• Study Start: December 1, 2023
• Primary Completion: December 1, 2024
• Study Completion: February 1, 2025
• Last Updated: November 13, 2023

Record last verified: 2023-11