NCT06527521

Brief Summary

This study aims to determine the frequency of amyloidosis among patients undergoing trauma surgery.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
246

participants targeted

Target at P75+ for all trials

Timeline
5mo left

Started Nov 2024

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress79%
Nov 2024Oct 2026

First Submitted

Initial submission to the registry

July 25, 2024

Completed
5 days until next milestone

First Posted

Study publicly available on registry

July 30, 2024

Completed
4 months until next milestone

Study Start

First participant enrolled

November 13, 2024

Completed
1.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2026

Expected
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2026

Last Updated

December 2, 2025

Status Verified

December 1, 2025

Enrollment Period

1.7 years

First QC Date

July 25, 2024

Last Update Submit

December 1, 2025

Conditions

Keywords

AmyloidosisRed Flags toolTraumatology

Outcome Measures

Primary Outcomes (1)

  • Amyloidosis

    Proportion of patients undergoing scheduled orthopedic surgery who are diagnosed with amyloidosis.

    One month

Interventions

Patients undergoing trauma surgery

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients included in the waiting list for scheduled trauma surgery

You may qualify if:

  • Men and women included in the waiting list for scheduled trauma surgery with at least one of the following criteria defined as red flags: Over 65 years old; Possible family history of amyloidosis, Cardiac pathology: aortic stenosis, presence of left ventricular hypertrophy defined as interventricular septal thickness \> 12mm measured by echocardiography, history of previous brady- or tachyarrhythmias including cardiac conduction blocks, history of syncope or presyncope, pro BNP \> 300 in previous blood tests; History of sensory peripheral neuropathy; History of nephropathy without etiological diagnosis; History of liver disease without a clear cause.
  • Ability to cooperate in the necessary evaluations.

You may not qualify if:

  • \- Participants previously diagnosed with amyloidosis cannot be included in the study.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Consorci Sanitari Alt Penedes i Garraf-Hospital Sant Camil

Sant Pere de Ribes, Barcelona, 08810, Spain

RECRUITING

MeSH Terms

Conditions

Amyloidosis

Condition Hierarchy (Ancestors)

Proteostasis DeficienciesMetabolic DiseasesNutritional and Metabolic Diseases

Study Officials

  • Lidia Tikhomirova, MD

    CSAPG

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Lidia Tikhomirova, MD

CONTACT

Noemí Casaponsa

CONTACT

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 25, 2024

First Posted

July 30, 2024

Study Start

November 13, 2024

Primary Completion (Estimated)

August 1, 2026

Study Completion (Estimated)

October 1, 2026

Last Updated

December 2, 2025

Record last verified: 2025-12

Data Sharing

IPD Sharing
Will share

IPD (without personal identification data) could be shared by requirement from other researchers after the end of the study, and only for research purposes and previous approval of promotor center of the study (CSAPG). Anyway, Spanish and European Union legal policy about data protection will strictly be followed (IPD will not be transferred outside European Union).

Shared Documents
STUDY PROTOCOL, ICF
Time Frame
After publication of main results of the study.
Access Criteria
IPD will be shared only for scientific research purposes and following the Spanish and European Union normative law about data protection. The requirements will be directed to the IP of the study. The IP will evaluate the request to verify and evaluate the data that is requested and the purposes for which it is requested. Next, the IP will transfer the request to the promotor center the study for the final decision.

Locations