MOSAiC
Medium to Long-term Outcomes After Selective Dorsal Rhizotomy in Ambulatory Children and Young People With Cerebral Palsy: A Mixed-methods Study
Sponsor study identifier
observational
90
1 country
1
Study Start
June 25, 2024
Actual (reported)Primary Completion
December 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
May 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
The main purpose of this study is to investigate the medium to long-term outcomes (3-10 years) after Selective Dorsal Rhizotomy (SDR) in ambulatory children and young people with cerebral palsy. The participants will complete a survey, come to hospital for some measurements and tests. Some parents and children and young people will also be invited to take part in an interview to understand their experiences of SDR.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
May 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
June 25, 2024
Actual (reported)July 18, 2024
Actual (reported)July 24, 2024
Actual (reported)December 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
May 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Gross Motor Function Measure (GMFM)
It is a clinical tool designed to evaluate changes in gross motor function in children with cerebral palsy. Performance-based observational tool
Single time-point at the follow-up.
Cerebral Palsy Quality of Life (CPQoL)
It is a validated tool designed to assess the Quality of Life for children with cerebral palsy across a variety of domains including social wellbeing and acceptance, feelings about functioning, participation and physical health, emotional wellbeing and self-esteem, access to services, pain and impact of disability, and family and parent health.
Single time-point; Parent and CYP questionnaire included in the online survey
6- Minute Walk Test
Used to test walking capacity and endurance in children with cerebral palsy. Children use their usual walking aids, footwear and orthoses.
Single time-point at the follow-up.
Functional Mobility Scale (FMS)
The FMS is a performance measure, classifying mobility on the basis of the use of mobility devices across three distances, 5m, 50m, and 500m, which represent home, school, and community distances. The mobility of the child is scored from 1 to 6 for each distance, with 1 representing use of a wheelchair and 6 representing independence on all surfaces.
Single time-point; Parent and CYP questionnaire included in the online survey
Modified Ashworth Scale (MAS)
Single time-point at the follow-up.
Edinburgh Visual Gait Analysis Scale (EVGS)
Single time-point at the follow-up.
Gait Outcome Assessment List questionnaire (GOAL)
Single time-point; CYP questionnaire included in the online survey
Functional Assessment Questionnaire (FAQ)
Single time-point; included in the online survey
Selective Motor Control (SMC)
Single time-point at the follow-up.
Selective Dorsal Rhizotomy (SDR) is an irreversible neurosurgical procedure where 50-70% of the sensory nerve roots are cut at the spinal level. The procedure is used to reduce lower limb spasticity permanently and is augmented by intensive rehabilitation for at least two years after surgery to optimise outcomes.
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Children and young people with cerebral palsy who had SDR surgery at Great Ormond Street Hospital (GOSH)
Great Ormond Street Hospital for Children
London, WC1N 3JH, United Kingdom
Chugh D, Kilbride C, Gimeno H, Aquilina K, Alderson L, Theologis T, Main E. Mixed-methods study exploring medium to longer-term outcomes following selective dorsal rhizotomy in ambulatory children with cerebral palsy at a tertiary hospital in the UK: MOSAiC study protocol. BMJ Open. 2025 Dec 8;15(12):e108558. doi: 10.1136/bmjopen-2025-108558.
Eleanor Main
Great Ormond Street Institute of Child Health, University College London
First Submitted
July 18, 2024
First Posted
July 24, 2024
Study Start
June 25, 2024
Actual (reported)Primary Completion
December 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Long-term Outcomes of Selective Dorsal Rhizotomy Among Individuals With Cerebral Palsy
Contact the study team to confirm eligibility.
Study Completion
May 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
July 24, 2024
Record last verified: 2024-07
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Source: ClinicalTrials.gov.
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