NCT03079362

Brief Summary

The study evaluates the anatomical distribution of the assessed Electromyogram (EMG) responses ensuring after sensory nerve root stimulation and obtained IOM grading during selective dorsal rhizotomy (SDR) with regard to level and, side of the body and gender as well as pain management and outcome data.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
148

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Jan 2007

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 15, 2007

Completed
7.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 27, 2014

Completed
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

December 2, 2015

Completed
1.3 years until next milestone

First Submitted

Initial submission to the registry

March 8, 2017

Completed
6 days until next milestone

First Posted

Study publicly available on registry

March 14, 2017

Completed
Last Updated

January 4, 2018

Status Verified

January 1, 2018

Enrollment Period

7.9 years

First QC Date

March 8, 2017

Last Update Submit

January 2, 2018

Conditions

Outcome Measures

Primary Outcomes (1)

  • The frequency distribution pattern of the grading assessed by SDR monitoring Electromyogram (EMG) procedure

    During the operation

Secondary Outcomes (25)

  • Intensive care unit length of stay

    Participants will be followed for the duration of hospital stay, an expected average of 1 day

  • Length of hospital stay

    Participants will be followed for the duration of hospital stay, an expected average of 7 days

  • Ready to discharge

    Participants will be followed for the duration of hospital stay, an expected average of 7 days

  • Duration of ventilation

    Participants will be followed for the duration of intensive care unit stay, an expected average of 1 day

  • Pain

    Up to 12 months

  • +20 more secondary outcomes

Study Arms (1)

Children

Children who underwent selective dorsal rhizotomy (SDR) including intraoperative neuromonitoring (IOM)

Eligibility Criteria

Age2 Years - 21 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64)
Sampling MethodProbability Sample
Study Population

Male and female pediatric and adolescent patients undergoing SDR

You may qualify if:

  • Male and female children with spastic cerebral palsy undergoing selective dorsal rhizotomy surgery including intraoperative neuromonitoring

You may not qualify if:

  • \> 21 years

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Department of Anesthesiology and Intensive Care Medicine CVK/CCM, Charité University Medicine -Berlin

Berlin, 13353, Germany

Location

Related Publications (1)

  • Wolter S, Spies C, Martin JH, Schulz M, Sarpong-Bengelsdorf A, Unger J, Thomale UW, Michael T, Murphy JF, Haberl H. Frequency distribution in intraoperative stimulation-evoked EMG responses during selective dorsal rhizotomy in children with cerebral palsy-part 1: clinical setting and neurophysiological procedure. Childs Nerv Syst. 2020 Sep;36(9):1945-1954. doi: 10.1007/s00381-020-04734-z. Epub 2020 Jun 23.

MeSH Terms

Conditions

Cerebral Palsy

Condition Hierarchy (Ancestors)

Brain Damage, ChronicBrain DiseasesCentral Nervous System DiseasesNervous System Diseases

Study Officials

  • Claudia Spies, MD, Prof.

    Charite University, Berlin, Germany

    STUDY DIRECTOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Department of Anesthesiology and Intensive Care Medicine CVK/CCM, Charite University, Berlin, Germany

Study Record Dates

First Submitted

March 8, 2017

First Posted

March 14, 2017

Study Start

January 15, 2007

Primary Completion

November 27, 2014

Study Completion

December 2, 2015

Last Updated

January 4, 2018

Record last verified: 2018-01

Data Sharing

IPD Sharing
Will not share

Locations