Effects of Corticosteroid Use on Restoration of Spontaneous Circulation in Cardiac Arrest Patients

NCT06515327 | Not Yet Recruiting

• 1 other identifier: Corticosteroid Cardiac Arrest
• Study Type: observational
• Target: 46
• Locations: 1 country
• Sites: 1

Brief Summary

We aim to investigate the effects of pre-arrest corticosteroid use for any reason on the time of return of spontaneous circulation in patients experiencing witnessed cardiac arrest, either in-hospital or out-of-hospital. Additionally, we plan to study the effects of corticosteroid use on post-ROSC administration of vasoactive agents, required dosage of vasoactive agents and number of vasoactive agents needed in order to reach targeted blood pressure levels.

Conditions

Cardiopulmonary Arrest; Corticosteroids Adverse Reaction

Keywords

Cardiac Arrest, Corticosteroids Use,

Outcome Measures

Primary Outcomes (1)

• return of spontaneous circulation

  patients with return of spontaneous circulation within 20 minutes of cardiopulmonary resuscitation

  20 minutes after cardiac arrest

Study Arms (2)

Steroid Group

Patients using corticosteroids for any reason before cardiac arrest

Non-Steroid Group

Patients not using corticosteroids and having cardiac arrest

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

patients over the age of 18 with witnessed cardiac arrest

You may qualify if:

• Age 18 and above Witnessed cardiac arrest

You may not qualify if:

• Traumatic cardiac arrest Forensic cases Cardiac arrest secondary to ST-elevation myocardial infarction Patients in whom spontaneous circulation could not be achieved despite cardiopulmonary resuscitation lasting more than 20 minutes Patients with inaccessible past medical records or unknown medication history Patients without identification Unwitnessed cardiac arrest Pregnant patients

Sponsors & Collaborators

• Saglik Bilimleri Universitesi: lead
• Ankara Etlik City Hospital: collaborator
• Etimesgut Military Hospital: collaborator

Study Sites (1)

Etlik City Hospital

Ankara, Yenimahalle, 06170, Turkey (Türkiye)

Location

Related Publications (3)

• Obling LER, Beske RP, Meyer MAS, Grand J, Wiberg S, Mohr T, Damm-Hejmdal A, Forman JL, Frikke-Schmidt R, Folke F, Moller JE, Kjaergaard J, Hassager C. Effect of prehospital high-dose glucocorticoid on hemodynamics in patients resuscitated from out-of-hospital cardiac arrest: a sub-study of the STEROHCA trial. Crit Care. 2024 Jan 22;28(1):28. doi: 10.1186/s13054-024-04808-3.

  PMID: 38254130 BACKGROUND

• Bagate F, Coppens A, Masi P, de Prost N, Carteaux G, Razazi K, Mekontso Dessap A. Cardiac and vascular effects of low-dose steroids during the early phase of septic shock: An echocardiographic study. Front Cardiovasc Med. 2022 Sep 26;9:948231. doi: 10.3389/fcvm.2022.948231. eCollection 2022.

  PMID: 36225952 BACKGROUND

• Ullian ME. The role of corticosteriods in the regulation of vascular tone. Cardiovasc Res. 1999 Jan;41(1):55-64. doi: 10.1016/s0008-6363(98)00230-2. No abstract available.

  PMID: 10325953 BACKGROUND

MeSH Terms

Conditions

Heart Arrest

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Study Officials

• gulsen akcay, ass. prof.

  ass. prof. of organization

  STUDY DIRECTOR

Central Study Contacts

gulsen akcay, ass. prof.

CONTACT

+905052874949; gulakcay@yahoo.com.tr

elif hamzacebioglu kayisoglu, specialist

CONTACT

+905453300679; turkuaz-61@windowslive.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Month
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 9, 2024
• First Posted: July 23, 2024
• Study Start: August 1, 2024
• Primary Completion: August 1, 2025
• Study Completion: August 1, 2025
• Last Updated: July 23, 2024

Record last verified: 2024-07

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)