Metabolomics Analysis of Acute Kidney Injury and Delirium After Cardiac Surgery

NCT06508593 | Completed

• 1 other identifier: KY20242228-C-1
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

Clinical evidence suggests that renal injury leads to changes in the structure of the cerebral cortex in patients, suggesting the existence of the renal brain axis. Therefore, some scholars have proposed that AKI may be an important cause of secondary injuries such as delirium. Approximately 60% of AKI patients in clinical practice experience delirium.Although the underlying mechanism associated with acute renal injury and delirium is still unclear, it has been recognized that it increases incidence rate and mortality, prolongs hospital stay, and accelerates long-term cognitive decline. The investigators assume that the serum metabolic profiles of patients with delirium and AKI after cardiac surgery, with delirium only, with AKI only, and without delirium or AKI after surgery can be compared separately to explore the mechanisms of complications and the interaction mechanisms between organ damage after extracorporeal circulation cardiac surgery, and to identify metabolic markers specific to complications, identify patients with increased susceptibility, and provide reference for early diagnosis of complications and basis for early intervention.

Conditions

AKI - Acute Kidney Injury; Delirium, Postoperative

Keywords

AKI; Delirium; Cardiac surgery; Metabolomics

Outcome Measures

Primary Outcomes (1)

• Small molecule metabolites specific to complications after extracorporeal circulation cardiac surgery

  Non biased detection of all small molecule metabolites associated with complications after extracorporeal circulation cardiac surgery, and screening of differential metabolites

  1 week

Study Arms (4)

AKI group

Patients developed AKI after cardiac surgery

Diagnostic Test: Serum metabolic profile

Delirium group

Patients developed delirium 5 days after cardiac surgery

Diagnostic Test: Serum metabolic profile

AKI and delirium group

Patients developed AKI and delirium after cardiac surgery

Diagnostic Test: Serum metabolic profile

Control group

Patients didn't develope AKI or delirium after cardiac surgery

Diagnostic Test: Serum metabolic profile

Interventions

Serum metabolic profile DIAGNOSTIC_TEST

Venous serum samples were analyzed for serum metabolic profiles using liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS) non targeted metabolomics techniques

AKI and delirium group; AKI group; Control group; Delirium group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients undergone extracorporeal circulation cardiac surgery

You may qualify if:

• years old and above
• Patients undergone elective cardiac surgery
• History of serum creatinine test within 7 days before surgery
• Provide venous blood samples
• Voluntarily participate and sign an informed consent form

You may not qualify if:

• Patients treated with chronic peritoneum or hemodialysis, prior kidney transplantation, preoperative serum creatinine level\>4.5mg/dL (400 μ mol/L) or end-stage renal disease (defined as glomerular filtration rate\<15ml · min-1 · 1.73m-2)
• Other related diseases that have been previously confirmed to have cognitive impairment, or records of using drugs targeting cognitive impairment during the onset period
• Individuals with severe speech, visual, hearing, or mental impairments that affect cognitive scale assessment
• Individuals with a history of brain tumors, traumatic brain injury, brain parasitic diseases, and other diseases that may cause cognitive impairment
• Individuals with a history of alcohol and drug addiction
• Pregnant and lactating women

Sponsors & Collaborators

• Xijing Hospital: lead

Study Sites (1)

Xijing Hospital

Xi'an, Shaanxi, 710032, China

Location

Related Publications (1)

• Liu M, Liang Y, Chigurupati S, Lathia JD, Pletnikov M, Sun Z, Crow M, Ross CA, Mattson MP, Rabb H. Acute kidney injury leads to inflammation and functional changes in the brain. J Am Soc Nephrol. 2008 Jul;19(7):1360-70. doi: 10.1681/ASN.2007080901. Epub 2008 Apr 2.

  PMID: 18385426 BACKGROUND

Biospecimen

Retention: SAMPLES WITHOUT DNA

Serum

MeSH Terms

Conditions

Acute Kidney Injury; Emergence Delirium; Delirium

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Confusion; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Neurocognitive Disorders; Mental Disorders

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator, Head of Anesthesia Clinical Research Center, Xijing Hospital

Study Record Dates

• First Submitted: July 12, 2024
• First Posted: July 18, 2024
• Study Start: July 20, 2024
• Primary Completion: December 31, 2024
• Study Completion: December 31, 2024
• Last Updated: April 6, 2025

Record last verified: 2025-04

Locations

CN (1)